Publication Name	World Journal of Gastroenterology
Manuscript ID	26010
Country	China

Received	2016-03-28 14:45
Peer-Review Started	2016-03-28 15:17
To Make the First Decision	2016-05-12 14:29
Return for Revision	2016-05-13 09:04
Revised	2016-06-07 22:29
Second Decision	2016-06-28 09:06
Accepted by Journal Editor-in-Chief	2016-07-01 01:05
Accepted by Executive Editor-in-Chief	2016-07-21 15:52
Articles in Press	2016-07-21 15:52
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-07-26 06:50
Typeset the Manuscript	2016-08-24 22:01
Publish the Manuscript Online	2016-09-04 14:49

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/ licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Review
Article Title	Aberrant regulation of Wnt signaling in hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Li-Juan Liu, Shui-Xiang Xie, Ya-Tang Chen, Jing-Ling Xue, Chuan-Jie Zhang and Fan Zhu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 31470264 National Natural Science Foundation of China 81502418 Key Program of Natural Science Foundation of Hubei Province of China 2014CFA078 Hubei Provincial Natural Science Foundation of China 2015CFB168and Hubei Provincial Natural Science Foundation of China 2012FFB04304 Scientific Research Innovation Team in Hubei 2015CFA009 General Financial Grant from the China Postdoctoral Science Foundation 2014M550411 Fundamental Research Funds for the Central Universities 2042014kf0029 Tianqing Liver Disease Research Fund of the China Foundation for Hepatitis Prevention and Control TQGB20140250 Innovation Seed Fund of Wuhan University School of Medicine; the Science and Technology Department Supported Program of Jiangxi Province of China 2010BSA13500 Science and Technology Project of Education Department of Jiangxi Province of China GJJ11570
Corresponding Author	Fan Zhu, PhD, Professor, Department of Medical Microbiology, School of Medicine, Wuhan University, 185 Donghu Road, Wuhan 430071, Hubei Province, China. fanzhu@whu.edu.cn
Key Words	Hepatocellular carcinoma; Wingless/int-1; Catenin β1; Crosstalk; Canonical wingless/int-1 signaling; Non-canonical wingless/int-1 signaling
Core Tip	The development of hepatocellular carcinoma (HCC) is regarded as a multistage process in which multiple genetic alterations are necessary. The wing-less/int-1 (Wnt) pathway is a signaling mechanism that is frequently activated in HCC, especially the canonical Wnt pathway. Moreover, two main non-canonical pathways are also involved in the regula-tion of hepatocarcinogenesis. Interestingly, the non-canonical Wnt pathway could antagonize the canonical Wnt pathway in HCC. Crosstalk between other signaling pathways and the Wnt pathway has also been shown to promote tumorigenesis. This review highlights the details regarding the Wnt pathway in HCC, which might provide new potential targets for HCC prevention and therapy.
Publish Date	2016-09-04 14:49
Citation	Liu LJ, Xie SX, Chen YT, Xue JL, Zhang CJ, Zhu F. Aberrant regulation of Wnt signaling in hepatocellular carcinoma. World J Gastroenterol 2016; 22(33): 7486-7499
URL	http://www.wjgnet.com/1007-9327/full/v22/i33/7486.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i33.7486

Full Article (PDF)	WJG-22-7486.pdf
Full Article (Word)	WJG-22-7486.doc
Manuscript File	26010-Review.docx
Answering Reviewers	26010-Answering reviewers.pdf
Audio Core Tip	26010-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	26010-Conflict-of-interest statement.pdf
Copyright License Agreement	26010-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	26010-Grant application form(s).pdf
Peer-review Report	26010-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	26010-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	26010-Scientific misconduct check.pdf
Scientific Editor Work List	26010-Scientific editor work list.pdf