Publication Name	World Journal of Gastroenterology
Manuscript ID	26014
Country	Slovakia

Received	2016-03-28 10:28
Peer-Review Started	2016-03-28 10:35
To Make the First Decision	2016-05-12 14:29
Return for Revision	2016-05-13 09:04
Revised	2016-05-26 16:59
Second Decision	2016-06-06 08:20
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-06-15 19:03
Articles in Press	2016-06-15 19:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-07-11 14:27
Publish the Manuscript Online	2016-07-15 15:38

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Pleiotropic effects of statins in the diseases of the liver
Manuscript Source	Invited Manuscript
All Author List	Martin Janicko, Sylvia Drazilova, Daniel Pella, Jan Fedacko and Peter Jarcuska
Funding Agency and Grant Number
Corresponding Author	Peter Jarcuska, MD, PhD, Associate Professor, 1st Department of Internal medicine, Pavol Jozef Safarik University in Kosice, Louis Pasteur University hospital, 04001 Kosice, Slovakia. petjarc@yahoo.com
Key Words	Statins; Hepatitis; Cirrhosis; Esophageal varices; Hepatocellular carcinoma
Core Tip	The greatest benefit of statins seems to be in patients with advanced liver disease. Observational studies suggest that statins have an antifibrotic effect possibly through the prevention of hepatic sinusoidal microthrombosis, reduce the rate of infections and decrease the risk of hepatocellular carcinoma in all cirrhotics, but particularly in patients with chronic hepatitis B and C. Data from randomized controlled trials confirmed that statins decrease hepatic vein pressure gradient, prevent re-bleeding, and improve the survival of patients after variceal bleeding. Statins also seem to prolong the survival of patients with advanced hepatocellular carcinoma even more than those treated with Sorafenib, which is the current standard of care for these patients.
Publish Date	2016-07-15 15:38
Citation	Janicko M, Drazilova S, Pella D, Fedacko J, Jarcuska P. Pleiotropic effects of statins in the diseases of the liver. World J Gastroenterol 2016; 22(27): 6201-6213
URL	http://www.wjgnet.com/1007-9327/full/v22/i27/6201.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i27.6201

Full Article (PDF)	WJG-22-6201.pdf
Full Article (Word)	WJG-22-6201.doc
Manuscript File	26014-Review.docx
Answering Reviewers	26014-Answering reviewers.pdf
Audio Core Tip	26014-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	26014-Conflict-of-interest statement.pdf
Copyright License Agreement	26014-Copyright assignment.pdf
Peer-review Report	26014-Peer-review(s).pdf
Scientific Misconduct Check	26014-Scientific misconduct check.pdf
Scientific Editor Work List	26014-Scientific editor work list.pdf