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7/15/2016 3:38:00 PM | Browse: 667 | Download: 992
Publication Name World Journal of Gastroenterology
Manuscript ID 26014
Country/Territory Slovakia
2016-03-28 10:28
Peer-Review Started
2016-03-28 10:35
To Make the First Decision
2016-05-12 14:29
Return for Revision
2016-05-13 09:04
2016-05-26 16:59
Second Decision
2016-06-06 08:20
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-06-15 19:03
Articles in Press
2016-06-15 19:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-07-11 14:27
Publish the Manuscript Online
2016-07-15 15:38
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Pleiotropic effects of statins in the diseases of the liver
Manuscript Source Invited Manuscript
All Author List Martin Janicko, Sylvia Drazilova, Daniel Pella, Jan Fedacko and Peter Jarcuska
Funding Agency and Grant Number
Corresponding author Peter Jarcuska, MD, PhD, Associate Professor, 1st Department of Internal medicine, Pavol Jozef Safarik University in Kosice, Louis Pasteur University hospital, 04001 Kosice, Slovakia. petjarc@yahoo.com
Key Words Statins; Hepatitis; Cirrhosis; Esophageal varices; Hepatocellular carcinoma
Core Tip The greatest benefit of statins seems to be in patients with advanced liver disease. Observational studies suggest that statins have an antifibrotic effect possibly through the prevention of hepatic sinusoidal microthrombosis, reduce the rate of infections and decrease the risk of hepatocellular carcinoma in all cirrhotics, but particularly in patients with chronic hepatitis B and C. Data from randomized controlled trials confirmed that statins decrease hepatic vein pressure gradient, prevent re-bleeding, and improve the survival of patients after variceal bleeding. Statins also seem to prolong the survival of patients with advanced hepatocellular carcinoma even more than those treated with Sorafenib, which is the current standard of care for these patients.
Publish Date 2016-07-15 15:38
Citation Janicko M, Drazilova S, Pella D, Fedacko J, Jarcuska P. Pleiotropic effects of statins in the diseases of the liver. World J Gastroenterol 2016; 22(27): 6201-6213
Url http://www.wjgnet.com/1007-9327/full/v22/i27/6201.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i27.6201
Full Article (PDF) WJG-22-6201.pdf
Full Article (Word) WJG-22-6201.doc
Manuscript File 26014-Review.docx
Answering Reviewers 26014-Answering reviewers.pdf
Audio Core Tip 26014-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 26014-Conflict-of-interest statement.pdf
Copyright License Agreement 26014-Copyright assignment.pdf
Peer-review Report 26014-Peer-review(s).pdf
Scientific Misconduct Check 26014-Scientific misconduct check.pdf
Scientific Editor Work List 26014-Scientific editor work list.pdf