Publication Name	World Journal of Gastroenterology
Manuscript ID	26015
Country	United Kingdom

Received	2016-03-28 10:34
Peer-Review Started	2016-03-28 11:13
To Make the First Decision	2016-05-12 14:29
Return for Revision	2016-05-13 09:05
Revised	2016-05-25 00:00
Second Decision	2016-06-06 08:20
Accepted by Journal Editor-in-Chief	2016-06-07 05:16
Accepted by Company Editor-in-Chief	2016-06-15 19:04
Articles in Press	2016-06-15 19:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-06-27 10:36
Publish the Manuscript Online	2016-07-06 16:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Role of inflammation and infection in the pathogenesis of human acute liver failure: Clinical implications for monitoring and therapy
Manuscript Source	Invited Manuscript
All Author List	Mhairi C Donnelly, Peter C Hayes and Kenneth J Simpson
Funding Agency and Grant Number
Corresponding Author	Dr. Mhairi C Donnelly, Department of Hepatology and Scottish Liver Transplant Unit, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, United Kingdom. mhairi.donnelly@nhs.net
Key Words	Inflammation; Neuroinflammation; Acute liver failure; Biomarker; Infection
Core Tip	Acute liver failure is a serious and rare condition, for which emergency liver transplantation is the only rescue therapy in advanced cases. The medical need for liver transplantation and feasibility of such an intervention are affected by the presence of systemic inflammation and infection. This review will discuss current thinking with regards to the role of infection and inflammation in the pathogenesis of human acute liver failure, and its effect on outcome. We also provide clinical guidance for the management of these patients and suggest directions for future research.
Publish Date	2016-07-06 16:53
Citation	Donnelly MC, Hayes PC, Simpson KJ. Role of inflammation and infection in the pathogenesis of human acute liver failure: Clinical implications for monitoring and therapy. World J Gastroenterol 2016; 22(26): 5958-5970
URL	http://www.wjgnet.com/1007-9327/full/v22/i26/5958.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i26.5958

Full Article (PDF)	WJG-22-5958.pdf
Full Article (Word)	WJG-22-5958.doc
Manuscript File	26015-Review.doc
Answering Reviewers	26015-Answering reviewers.pdf
Audio Core Tip	26015-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	26015-Conflict-of-interest statement.pdf
Copyright License Agreement	26015-Copyright assignment.pdf
Peer-review Report	26015-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	26015-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	26015-Scientific misconduct check.pdf
Scientific Editor Work List	26015-Scientific editor work list.pdf