| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Autobiography |
| Article Title |
Krüppel-like factor 8 overexpression is correlated with angiogenesis and poor prognosis in gastric cancer
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Wen-Fei Wang, Juan Li, Lu-Tao Du, Li-Li Wang, Yong-Mei Yang, Yi-Min Liu, Hui Liu, Xin Zhang, Zhao-Gang Dong, Gui-Xi Zheng and Chuan-Xin Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shandong Province Natural Science Foundation of China |
ZR2010HZ004 |
| National Key Clinical Medical Specialties Foundation |
|
|
| Corresponding Author |
Chuan-Xin Wang, Professor, Department of Clinical Laboratory, Qilu Hospital, Shandong University, 107 Wenhua Xi Road, Jinan 250012, Shandong Province, China. cxwang@sdu.edu.cn |
| Key Words |
Gastric cancer; Krüppel-like factor 8; Angiogenesis; Prognosis |
| Core Tip |
In this study, we found that the expression of Krüppel-like factor 8 (KLF8) was up-regulated in resected gastric cancer tissues. The differential KLF8 expression was significantly associated with enhanced malignant potential, including tumor size, local invasion, regional lymph node metastasis, distant metastasis, and tumor node metastasis stage, as well as the intratumoral microvessel density. Multivariate analysis indicated that KLF8 expression independently affected both overall and cancer-specific survival of gastric cancer patients. Collectively, our findings suggest that KLF8 may be a predictive marker of clinical outcome and represent a novel target for anti-angiogenic therapy of gastric cancer patients. |
| Publish Date |
2013-07-20 20:47 |
| Citation |
Wang WF, Li J, Du LT, Wang LL, Yang YM, Liu YM, Liu H, Zhang X, Dong ZG, Zheng GX, Wang CX. Krüppel-like factor 8 overexpression is correlated with angiogenesis and poor prognosis in gastric cancer. World J Gastroenterol 2013; 19(27): 4309-4315 |
| URL |
http://www.wjgnet.com/1007-9327/full/v19/i27/4309.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v19.i27.4309 |
