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9/15/2014 8:54:00 PM | Browse: 468 | Download: 413
Publication Name World Journal of Gastroenterology
Manuscript ID 2605
Country/Territory China
2013-03-03 17:14
Peer-Review Started
2013-03-04 09:56
To Make the First Decision
2013-03-25 15:14
Return for Revision
2013-04-01 14:54
2013-04-30 13:48
Second Decision
2013-06-19 12:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-06-20 00:57
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-07-11 09:29
Publish the Manuscript Online
2013-07-20 20:47
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research and Experimental
Manuscript Type Autobiography
Article Title Krüppel-like factor 8 overexpression is correlated with angiogenesis and poor prognosis in gastric cancer
Manuscript Source Invited Manuscript
All Author List Wen-Fei Wang, Juan Li, Lu-Tao Du, Li-Li Wang, Yong-Mei Yang, Yi-Min Liu, Hui Liu, Xin Zhang, Zhao-Gang Dong, Gui-Xi Zheng and Chuan-Xin Wang
Funding Agency and Grant Number
Funding Agency Grant Number
Shandong Province Natural Science Foundation of China ZR2010HZ004
National Key Clinical Medical Specialties Foundation
Corresponding author Chuan-Xin Wang, Professor, Department of Clinical Laboratory, Qilu Hospital, Shandong University, 107 Wenhua Xi Road, Jinan 250012, Shandong Province, China. cxwang@sdu.edu.cn
Keywords Gastric cancer; Krüppel-like factor 8; Angiogenesis; Prognosis
Core Tip In this study, we found that the expression of Krüppel-like factor 8 (KLF8) was up-regulated in resected gastric cancer tissues. The differential KLF8 expression was significantly associated with enhanced malignant potential, including tumor size, local invasion, regional lymph node metastasis, distant metastasis, and tumor node metastasis stage, as well as the intratumoral microvessel density. Multivariate analysis indicated that KLF8 expression independently affected both overall and cancer-specific survival of gastric cancer patients. Collectively, our findings suggest that KLF8 may be a predictive marker of clinical outcome and represent a novel target for anti-angiogenic therapy of gastric cancer patients.
Publish Date 2013-07-20 20:47
Citation Wang WF, Li J, Du LT, Wang LL, Yang YM, Liu YM, Liu H, Zhang X, Dong ZG, Zheng GX, Wang CX. Krüppel-like factor 8 overexpression is correlated with angiogenesis and poor prognosis in gastric cancer. World J Gastroenterol 2013; 19(27): 4309-4315
Url http://www.wjgnet.com/1007-9327/full/v19/i27/4309.htm
DOI http://dx.doi.org/10.3748/wjg.v19.i27.4309
Full Article (PDF) WJG-19-4309.pdf
Manuscript File 2605-Review.doc
Answering Reviewers 2605-Answering Reviewers.pdf
Copyright License Agreement 2605-Copyright Assignment.pdf
Non-Native Speakers of English Editing Certificate 2605-Language certificate.pdf
Peer-review Report 2605-Peer review(s).pdf
Scientific Editor Work List 2605-Scientific editor work list.doc