Publication Name	World Journal of Gastroenterology
Manuscript ID	26115
Country	China

Received	2016-03-29 21:05
Peer-Review Started	2016-04-01 17:20
To Make the First Decision	2016-05-30 09:21
Return for Revision	2016-05-30 13:18
Revised	2016-06-27 17:25
Second Decision	2016-07-21 18:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-08-01 15:50
Articles in Press	2016-08-01 15:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-08-12 19:44
Publish the Manuscript Online	2016-08-24 10:09

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Review
Article Title	Management of hepatocellular carcinoma with portal vein tumor thrombosis: Review and update at 2016
Manuscript Source	Invited Manuscript
All Author List	Stephen L Chan, Charing CN Chong, Anthony WH Chan, Darren MC Poon and Kenneth SH Chok
Funding Agency and Grant Number	Funding Agency Grant Number Hong Kong Research Grants Council General Research Fund Scheme 462013
Corresponding Author	Stephen L Chan, Department of Clinical Oncology, Sir YK Pao Center for Cancer, Hong Kong Cancer Institute, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China. chanlam_stephen@cuhk.edu.hk
Key Words	Liver cancer; Vascular invasion; Targeted agent; Surgery; Radiotherapy
Core Tip	Conventionally, the presence of portal vein tumor thrombosis (PVTT) indicated an extremely poor prognosis for hepatocellular carcinoma (HCC) patients and was considered a contraindication to both surgery and trans-arterial procedures. Recent studies indicate that HCC with PVTT represents a heterogeneous group with variable prognoses. Several classifications have been proposed to gauge the prognoses of PVTT. For selected patients with less severe PVTT, surgery with curative intent is feasible with favorable outcomes. Further, expanding treatment options, such as radiotherapy, radioembolization and systemic treatment, could improve the outcomes of patients with more severe forms of PVTT in patients with HCC.
Publish Date	2016-08-24 10:09
Citation	Chan SL, Chong CCN, Chan AWH, Poon DMC, Chok KSH. Management of hepatocellular carcinoma with portal vein tumor thrombosis: Review and update at 2016. World J Gastroenterol 2016; 22(32): 7289-7300
URL	http://www.wjgnet.com/1007-9327/full/v22/i32/7289.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i32.7289

Full Article (PDF)	WJG-22-7289.pdf
Full Article (Word)	WJG-22-7289.doc
Manuscript File	26115-Review.docx
Answering Reviewers	26115-Answering reviewers.pdf
Audio Core Tip	26115-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	26115-Conflict-of-interest statement.pdf
Copyright License Agreement	26115-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	26115-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	26115-Language certificate.pdf
Peer-review Report	26115-Peer-review(s).pdf
Scientific Misconduct Check	26115-Scientific misconduct check.pdf
Scientific Editor Work List	26115-Scientific editor work list.pdf