Publication Name	World Journal of Gastroenterology
Manuscript ID	26127
Country	Japan

Received	2016-04-01 10:10
Peer-Review Started	2016-04-02 23:12
To Make the First Decision	2016-05-12 15:34
Return for Revision	2016-05-13 16:14
Revised	2016-06-09 22:52
Second Decision	2016-06-23 17:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-07-06 18:43
Articles in Press	2016-07-06 18:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-07-28 15:42
Publish the Manuscript Online	2016-08-04 17:58

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Cancer-associated fibroblasts in hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Norio Kubo, Kenichiro Araki, Hiroyuki Kuwano and Ken Shirabe
Funding Agency and Grant Number	Funding Agency Grant Number Research Program on Hepatitis from Japan Agency for Medical Research and development, AMED
Corresponding Author	Kenichiro Araki, MD, PhD, Department of Hepatobiliary and Pancreatic Surgery, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan. karaki@gunma-u.ac.jp
Key Words	Cancer associated fibroblast; Hepatic stellate cell; Hepatocellular carcinoma; Immunosuppression; Therapeutic target
Core Tip	Cancer-associated fibroblasts (CAFs) are one of the most crucial components of the tumor microenvironment that promote the carcinogenesis, proliferation and invasion of cancer cells by secreting various growth factors and cytokines. In hepatocellular carcinoma (HCC), cirrhosis caused by chronic inflammation was considered the main reason for carcinogenesis, and field cancerization was explained by the epigenetic changes in fibroblasts in tissues surrounding the tumor. In this review, we discuss the findings from current literature on the role of CAFs in HCC. CAF-targeted therapy may be effective for suppression not only fibrosis but also cancer progression.
Publish Date	2016-08-04 17:58
Citation	Kubo N, Araki K, Kuwano H, Shirabe K. Cancer-associated fibroblasts in hepatocellular carcinoma. World J Gastroenterol 2016; 22(30): 6841-6850
URL	http://www.wjgnet.com/1007-9327/full/v22/i30/6841.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i30.6841

Full Article (PDF)	WJG-22-6841.pdf
Full Article (Word)	WJG-22-6841.doc
Manuscript File	26127-Review.docx
Answering Reviewers	26127-Answering reviewers.pdf
Audio Core Tip	26127-Audio core tip.MP3
Conflict-of-Interest Disclosure Form	26127-Conflict-of-interest statement.pdf
Copyright License Agreement	26127-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	Editing_Certificate_20160328224550.pdf
Peer-review Report	26127-Peer-review(s).pdf
Scientific Misconduct Check	26127-Scientific misconduct check.pdf
Scientific Editor Work List	26127-Scientific editor work list.pdf