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Articles Published Processes
7/22/2016 1:36:00 PM | Browse: 1196 | Download: 1606
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Received |
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2016-03-30 11:43 |
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Peer-Review Started |
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2016-04-04 14:47 |
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To Make the First Decision |
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2016-05-12 15:34 |
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Return for Revision |
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2016-05-13 16:32 |
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Revised |
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2016-06-11 02:52 |
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Second Decision |
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2016-06-23 17:28 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-07-06 18:46 |
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Articles in Press |
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2016-07-06 18:47 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-07-20 16:50 |
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Publish the Manuscript Online |
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2016-07-22 13:48 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Topic Highlights |
| Article Title |
Mechanisms of resistance to anti-epidermal growth factor receptor inhibitors in metastatic colorectal cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Vincenzo Sforza, Erika Martinelli, Fortunato Ciardiello, Valentina Gambardella, Stefania Napolitano, Giulia Martini, Carminia della Corte, Claudia Cardone, Marianna L Ferrara, Alfonso Reginelli, Giuseppina Liguori, Giulio Belli and Teresa Troiani |
| Funding Agency and Grant Number |
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| Corresponding Author |
Vincenzo Sforza, MD, Oncologia medica, Dipartimento di Medicina Clinica e Sperimentale “F. Magrassi e A. Lanzara”, Seconda Università degli Studi di Napoli, via S. Pansini 5, 80131 Naples, Italy. vincenzosforza83@gmail.com |
| Key Words |
Metastatic colorectal cancer; Epidermal growth factor receptor; Resistance; Mutation; KRAS; NRAS; BRAF; PIK3CA; MET; Monoclonal antibodies |
| Core Tip |
The treatment with anti-epidermal growth factor receptor (EGFR) monoclonal antibodies cetu-ximab and panitumumab in metastatic colorectal cancer is unfortunately burdened by the lack of clinical and molecular biomarkers that correlate with treatment response. Primary and acquired resistance have been shown to be the major culprits of the failure of anti-EGFR treatments. However, a deeper understanding of the molecular basis underlying both types of resistance has led to the proposal of several approaches designed to prevent, overcome or revert the drug resistance. Nevertheless, these approaches deserve further clinical investigation to allow us to use EGFR-targeted therapies more effectively in the correct population. |
| Publish Date |
2016-07-22 13:48 |
| Citation |
Sforza V, Martinelli E, Ciardiello F, Gambardella V, Napolitano S, Martini G, della Corte C, Cardone C, Ferrara ML, Reginelli A, Liguori G, Belli G, Troiani T. Mechanisms of resistance to anti-epidermal growth factor receptor inhibitors in metastatic colorectal cancer. World J Gastroenterol 2016; 22(28): 6345-6361 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i28/6345.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i28.6345 |
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