Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	26175
Country	Algeria

Received	2016-03-29 15:46
Peer-Review Started	2016-04-05 08:18
First Decision by Editorial Office Director
Return for Revision	2016-05-23 14:54
Revised	2016-06-10 12:45
Publication Fee Transferred
Second Decision by Editor	2016-07-04 17:10
Second Decision by Editor-in-Chief	2016-07-05 12:03
Final Decision by Editorial Office Director	2016-07-18 10:55
Articles in Press	2016-07-18 10:55
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-07-25 09:02
Publish the Manuscript Online	2016-08-01 11:49

ISSN	2150-5349 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Overview of cytokines and nitric oxide involvement in immuno-pathogenesis of inflammatory bowel diseases
Manuscript Source	Invited Manuscript
All Author List	Imene Soufli, Ryma Toumi, Hayet Rafa and Chafia Touil-Boukoffa
Funding Agency and Grant Number
Corresponding Author	Touil-Boukoffa Chafia, Professor, Department of Cellular and Molecular Biology, Cytokines and NOSynthases Team, University of Sciences and Technology Houari Boumediene, 16111 Algiers, Algeria. touilboukoffa@yahoo.fr
Key Words	Inflammatory bowel disease; Cytokines; Nitric oxide; Inducible nitric oxide synthase; Immuno-pathogenesis
Core Tip	Inflammatory bowel diseases (IBDs), including Crohn’s disease and ulcerative colitis are an immunolgically mediated disease with undetermined etiology. Evidence from animal and clinical studies demonstrate a positive correlation between an increased concentration of nitric oxide (NO) and the severity of the disease. Moreover, a positive correlation between NO production and increased pro-inflammatory cytokine levels [tumor necrosis factor-a, interleukin (IL)-6, IL-17, IL-12, and interferon-g] were reported in patients with IBD. This review focuses on the role of cytokines in intestinal inflammation and their relationship with NO in IBD.
Publish Date	2016-08-01 11:49
Citation	Soufli I, Toumi R, Rafa H, Touil-Boukoffa C. Overview of cytokines and nitric oxide involvement in immuno-pathogenesis of inflammatory bowel diseases. World J Gastrointest Pharmacol Ther 2016; 7(3): 353-360
URL	http://www.wjgnet.com/2150-5349/full/v7/i3/353.htm
DOI	http://dx.doi.org/10.4292/wjgpt.v7.i3.353

Full Article (PDF)	WJGPT-7-353.pdf
Full Article (Word)	WJGPT-7-353.doc
Manuscript File	26175-Review.doc
Answering Reviewers	26175-Answering reviewers.pdf
Audio Core Tip	26175-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	26175-Conflict-of-interest statement.pdf
Copyright License Agreement	26175-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	26175-Language certificate.pdf
Peer-review Report	26175-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	26175-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	26175-Scientific misconduct check.pdf
Scientific Editor Work List	26175-Scientific editor work list.pdf