Publication Name	World Journal of Gastroenterology
Manuscript ID	26208
Country	China

Received	2016-03-30 10:10
Peer-Review Started	2016-04-05 17:01
To Make the First Decision	2016-05-12 15:35
Return for Revision	2016-05-13 17:32
Revised	2016-05-27 10:33
Second Decision	2016-06-14 17:58
Accepted by Journal Editor-in-Chief	2016-06-16 13:04
Accepted by Executive Editor-in-Chief	2016-06-29 09:41
Articles in Press	2016-06-29 09:41
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-07-18 16:41
Typeset the Manuscript	2016-07-21 13:58
Publish the Manuscript Online	2016-07-29 20:32

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Progress in systemic therapy of advanced hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Xin-Lei Gong and Shu-Kui Qin
Funding Agency and Grant Number
Corresponding Author	Shu-Kui Qin, MD, Chinese People’s Liberation Army Cancer Center, Bayi Hospital, No. 34, 34 Biao, Yanggongjing Street, Nanjing 210002, Jiangsu Province, China. qinsk@csco.org.cn
Key Words	Hepatocellular carcinoma; Systemic therapy; Molecular targeted therapy; Chemotherapy; Progress
Core Tip	This review describes the progress in systemic therapy of advanced hepatocellular carcinoma (HCC) in recent years from several aspects. First, we describe the progress in molecular targeted therapy of HCC. Second, we highlight systemic chemotherapy especially oxaliplatin-based regimens. Third, we introduce some new information of immunotherapy and arginine deprivation therapy. At the end of the article, we have a brief summary and discuss the future direction of development.
Publish Date	2016-07-29 20:32
Citation	Gong XL, Qin SK. Progress in systemic therapy of advanced hepatocellular carcinoma. World J Gastroenterol 2016; 22(29): 6582-6594
URL	http://www.wjgnet.com/1007-9327/full/v22/i29/6582.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i29.6582

Full Article (PDF)	WJG-22-6582.pdf
Full Article (Word)	WJG-22-6582.doc
Manuscript File	26208-Review.docx
Answering Reviewers	26208-Answering reviewers.pdf
Audio Core Tip	26208-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	26208-Conflict-of-interest statement.pdf
Copyright License Agreement	26208-Copyright assignment.pdf
Peer-review Report	26208-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	26208-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	26208-Scientific misconduct check.pdf
Scientific Editor Work List	26208-Scientific editor work list.pdf