Publication Name	World Journal of Gastroenterology
Manuscript ID	26215
Country	Italy

Received	2016-04-04 19:29
Peer-Review Started	2016-04-05 17:27
To Make the First Decision	2016-05-12 15:36
Return for Revision	2016-05-13 17:40
Revised	2016-05-19 17:50
Second Decision	2016-06-01 18:26
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-06-13 18:25
Articles in Press	2016-06-13 18:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-06-28 19:48
Publish the Manuscript Online	2016-07-06 16:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Biochemistry & Molecular Biology
Manuscript Type	Basic Study
Article Title	Silybin counteracts lipid excess and oxidative stress in cultured steatotic hepatic cells
Manuscript Source	Invited Manuscript
All Author List	Giulia Vecchione, Elena Grasselli, Adriana Voci, Francesca Baldini, Ignazio Grattagliano, David QH Wang, Piero Portincasa and Laura Vergani
Funding Agency and Grant Number	Funding Agency Grant Number MIUR-COFIN, Compagnia San Paolo Torino, University of Genova 20089SRS2X_002 Fondazione CARIGE
Corresponding Author	Dr. Laura Vergani, DISTAV, Department of Earth, Environment and Life Sciences, University of Genova, Corso Europa 26, 16132 Genova, Italy. laura.vergani@unige.it
Key Words	Non-alcoholic fatty liver disease; Steatotic hepatocytes; Silybin; Lipid metabolism; Oxidative stress; Lipid droplets; Mitochondrialβ-oxidation
Core Tip	FaO hepatic cells loaded with lipids by exposure to oleate/palmitate mixture represent a widely accepted cellular model of hepatic steatosis. FaO steatotic cells were used to investigate in vitro the possible direct effects of silybin as phytosome complex with vitamin E on lipid accumulation and metabolism and on oxidative stress. We demonstrated the ability of silybin in reducing fat accumulation and improving the oxidative imbalance caused by lipid excess. The results may elucidate at a cellular level the encouraging results demonstrated for silybin in previous clinical and animal studies.
Publish Date	2016-07-06 16:53
Citation	Vecchione G, Grasselli E, Voci A, Baldini F, Grattagliano I, Wang DQH, Portincasa P, Vergani L. Silybin counteracts lipid excess and oxidative stress in cultured steatotic hepatic cells. World J Gastroenterol 2016; 22(26): 6016-6026
URL	http://www.wjgnet.com/1007-9327/full/v22/i26/6016.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i26.6016

Full Article (PDF)	WJG-22-6016.pdf
Full Article (Word)	WJG-22-6016.doc
Manuscript File	26215-Review.doc
Answering Reviewers	26215-Answering reviewers.pdf
Audio Core Tip	26215-Audio core tip.mp3
Copyright License Agreement	26215-Copyright assignment.pdf
Supplementary Material	Supplementary_Material_20160325194128.docx
Peer-review Report	26215-Peer-review(s).pdf
Scientific Misconduct Check	26215-Scientific misconduct check.pdf
Scientific Editor Work List	26215-Scientific editor work list.pdf