Publication Name	World Journal of Hematology
Manuscript ID	2626
Country	Netherlands

Received	2013-03-04 17:26
Peer-Review Started	2013-03-05 16:23
First Decision by Editorial Office Director
Return for Revision	2013-05-17 15:35
Revised
Publication Fee Transferred
Second Decision by Editor	2013-08-06 08:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-08-06 11:40
Articles in Press
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-09-29 14:13
Publish the Manuscript Online	2013-11-04 12:36

ISSN	2218-6204 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Hematology
Manuscript Type	Editorial
Article Title	Pseudohemophilia of Erik von Willebrand caused by homozygous one nucleotide deletion in exon 18 of the VW-factor gene
Manuscript Source	Invited Manuscript
All Author List	Alain Gadisseur, Zwi Berneman, Wilfried Schroyens and Jan Jacques Michiels
Funding Agency and Grant Number
Corresponding Author	Jan Jacques Michiels, Professor, Goodheart Institute and Foundation, Bloodcoagulation and Vascular Medicine Center, Erasmus Tower, Veenmos 13, 3069 AT Rotterdam, The Netherlands. goodheartcenter@upcmail.nl
Key Words	Autosomal recessive von Willebrand disease type 3 and 1; Molecular etiology; Carrier of von Willebrand disease null or missense allele; Desmopressin acetate responses
Core Tip	The novel lethal bleeding disorder described as “Hereditary Pseudohemophilia by von Willebrand (VW) in 1926 is caused by a homozygous nonsense mutation (one nucleotide deletion in exon 18) of the VW-factor gene consistent with autosomal recessive VW disease (VWD) type 3. Heterozygous carriers presented with VWD type 1 with variable penetrance of mild mucocutaneous bleeding manifestations. The present editorial reviews the clinical, laboratory and molecular features of severe recessive type 1 and 3 VWD and obligate heterozygous carriers of VWF nonsense and missense mutations.
Publish Date	2013-11-04 12:36
Citation	Gadisseur A, Berneman Z, Schroyens W, Michiels JJ. Pseudohemophilia of Erik von Willebrand caused by homozygous one nucleotide deletion in exon 18 of the VW-factor gene. World J Hematol 2013; 2(4): 99-108
URL	http://www.wjgnet.com/2218-6204/full/v2/i4/99.htm
DOI	http://dx.doi.org/10.5315/wjh.v2.i4.99

Full Article (PDF)	WJH-2-99.pdf
Manuscript File	2626-Review.doc
Answering Reviewers	2626-Answering reviewers.pdf
Peer-review Report	2626-Peer review(s).pdf
Scientific Editor Work List	2626-Scientific editor work list.doc