Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	26293
Country	United States

Received	2016-04-02 18:36
Peer-Review Started	2016-04-07 12:39
To Make the First Decision	2016-06-06 17:22
Return for Revision	2016-06-07 14:30
Revised	2016-07-07 00:00
Second Decision	2016-08-18 09:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-08-29 11:55
Articles in Press	2016-08-29 11:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-10-24 14:26
Publish the Manuscript Online	2016-10-31 09:01

ISSN	2150-5349 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Bilirubin in coronary artery disease: Cytotoxic or protective?
Manuscript Source	Invited Manuscript
All Author List	Nancy Gupta, Tavankit Singh, Rahul Chaudhary, Sushil K Garg, Gurprataap Singh Sandhu, Varun Mittal, Rahul Gupta, Roxana Bodin and Sachin Sule
Funding Agency and Grant Number
Corresponding Author	Nancy Gupta, MD, Department of Medicine, Westchester Medical Center, New York Medical College, 40 Sunshine Cottage Rd, Valhalla, NY 10595, United States. drnancygupta87@gmail.com
Key Words	Bilirubin; Cytotoxic; Protective; Anti-oxidant; Anti-inflammatory; Anti coronary artery disease; Lipid peroxidation; Gilbert
Core Tip	Bilirubin has traditionally been considered a cytotoxic waste product. However, recent studies have shown bilirubin to have anti-oxidant, anti-inflammatory, vasodilatory, anti-apoptotic and anti-proliferative functions. These properties potentially confer bilirubin a new role of protection especially in coronary artery disease (CAD), which is a low grade inflammatory process exacerbated by oxidative stress. In fact, recent literature reports an inverse relationship between serum concentration of bilirubin and the presence of CAD. In this article, we review the current literature exploring the association between levels of bilirubin and risk of CAD.
Publish Date	2016-10-31 09:01
Citation	Gupta N, Singh T, Chaudhary R, Garg SK, Sandhu GS, Mittal V, Gupta R, Bodin R, Sule S. Bilirubin in coronary artery disease: Cytotoxic or protective? World J Gastrointest Pharmacol Ther 2016; 7(4): 469-476
URL	http://www.wjgnet.com/2150-5349/full/v7/i4/469.htm
DOI	http://dx.doi.org/10.4292/wjgpt.v7.i4.469

Full Article (PDF)	WJGPT-7-469.pdf
Full Article (Word)	WJGPT-7-469.doc
Manuscript File	26293-Review.doc
Answering Reviewers	26293-Answering reviewers.pdf
Audio Core Tip	26293-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	26293-Conflict-of-interest statement.pdf
Copyright License Agreement	26293-Copyright assignment.pdf
Peer-review Report	26293-Peer-review(s).pdf
Scientific Misconduct Check	26293-Scientific misconduct check.pdf
Scientific Editor Work List	26293-Scientific editor work list.pdf