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8/1/2016 11:49:00 AM | Browse: 1108 | Download: 1296
Publication Name World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID 26325
Country/Territory United States
Received
2016-04-04 18:56
Peer-Review Started
2016-04-05 19:58
To Make the First Decision
2016-06-06 17:23
Return for Revision
2016-06-07 14:27
Revised
2016-06-13 22:22
Second Decision
2016-07-04 17:10
Accepted by Journal Editor-in-Chief
2016-07-05 12:09
Accepted by Company Editor-in-Chief
2016-07-18 10:56
Articles in Press
2016-07-18 10:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-07-25 09:02
Publish the Manuscript Online
2016-08-01 11:49
ISSN 2150-5349 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Topic Highlights
Article Title Management of pain in chronic pancreatitis with emphasis on exogenous pancreatic enzymes
Manuscript Source Invited Manuscript
All Author List Paul M Hobbs, William G Johnson and David Y Graham
Funding Agency and Grant Number
Corresponding Author David Y Graham, MD, Department of Medicine, Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, RM 3A-318B (111D), 2002 Holcombe Boulevard, Houston, TX 77030, United States. dgraham@bcm.edu
Key Words Pancreatic enzyme replacement therapy; Chronic pancreatitis; Pancreatic insufficiency; Protease; Clinical trials; Trypsin; Fat malabsorption; Pain
Core Tip Pancreatic enzyme replacement therapy has long been used as a non-invasive treatment for chronic pancreatic pain. Enzyme therapy aims to restore feedback inhibition of pancreatic secretion to lessen pain caused by pancreatic ductal hypertension, increased pancreatic interstitial pressure, and pancreatic ischemia. Although enzyme therapy may play a role the key is individualization of therapy based on disease etiology and severity. Here we review the literature regarding the efficacy of enzyme therapy and the evidence gathered for an entero-pancreatic feedback loop. We also describe alternative strategies for improving pain therapy including using uncoated enzymes with gastric acid suppression.
Publish Date 2016-08-01 11:49
Citation Hobbs PM, Johnson WG, Graham DY. Management of pain in chronic pancreatitis with emphasis on exogenous pancreatic enzymes. World J Gastrointest Pharmacol Ther 2016; 7(3): 370-386
URL http://www.wjgnet.com/2150-5349/full/v7/i3/370.htm
DOI http://dx.doi.org/10.4292/wjgpt.v7.i3.370
Full Article (PDF) WJGPT-7-370.pdf
Full Article (Word) WJGPT-7-370.doc
Manuscript File 26325-Review.doc
Answering Reviewers 26325-Answering reviewers.pdf
Audio Core Tip 26325-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 26325-Conflict-of-interest statement.pdf
Copyright License Agreement 26325-Copyright assignment.pdf
Peer-review Report 26325-Peer-review(s).pdf
Scientific Misconduct Check 26325-Scientific misconduct check.pdf
Scientific Editor Work List 26325-Scientific editor work list.pdf