Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	26325
Country	United States

Received	2016-04-04 18:56
Peer-Review Started	2016-04-05 19:58
To Make the First Decision	2016-06-06 17:23
Return for Revision	2016-06-07 14:27
Revised	2016-06-13 22:22
Second Decision	2016-07-04 17:10
Accepted by Journal Editor-in-Chief	2016-07-05 12:09
Accepted by Executive Editor-in-Chief	2016-07-18 10:56
Articles in Press	2016-07-18 10:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-07-25 09:02
Publish the Manuscript Online	2016-08-01 11:49

ISSN	2150-5349 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Management of pain in chronic pancreatitis with emphasis on exogenous pancreatic enzymes
Manuscript Source	Invited Manuscript
All Author List	Paul M Hobbs, William G Johnson and David Y Graham
Funding Agency and Grant Number
Corresponding Author	David Y Graham, MD, Department of Medicine, Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, RM 3A-318B (111D), 2002 Holcombe Boulevard, Houston, TX 77030, United States. dgraham@bcm.edu
Key Words	Pancreatic enzyme replacement therapy; Chronic pancreatitis; Pancreatic insufficiency; Protease; Clinical trials; Trypsin; Fat malabsorption; Pain
Core Tip	Pancreatic enzyme replacement therapy has long been used as a non-invasive treatment for chronic pancreatic pain. Enzyme therapy aims to restore feedback inhibition of pancreatic secretion to lessen pain caused by pancreatic ductal hypertension, increased pancreatic interstitial pressure, and pancreatic ischemia. Although enzyme therapy may play a role the key is individualization of therapy based on disease etiology and severity. Here we review the literature regarding the efficacy of enzyme therapy and the evidence gathered for an entero-pancreatic feedback loop. We also describe alternative strategies for improving pain therapy including using uncoated enzymes with gastric acid suppression.
Publish Date	2016-08-01 11:49
Citation	Hobbs PM, Johnson WG, Graham DY. Management of pain in chronic pancreatitis with emphasis on exogenous pancreatic enzymes. World J Gastrointest Pharmacol Ther 2016; 7(3): 370-386
URL	http://www.wjgnet.com/2150-5349/full/v7/i3/370.htm
DOI	http://dx.doi.org/10.4292/wjgpt.v7.i3.370

Full Article (PDF)	WJGPT-7-370.pdf
Full Article (Word)	WJGPT-7-370.doc
Manuscript File	26325-Review.doc
Answering Reviewers	26325-Answering reviewers.pdf
Audio Core Tip	26325-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	26325-Conflict-of-interest statement.pdf
Copyright License Agreement	26325-Copyright assignment.pdf
Peer-review Report	26325-Peer-review(s).pdf
Scientific Misconduct Check	26325-Scientific misconduct check.pdf
Scientific Editor Work List	26325-Scientific editor work list.pdf