Publication Name	World Journal of Hepatology
Manuscript ID	26349
Country	Pakistan

Received	2016-04-05 09:07
Peer-Review Started	2016-04-05 14:29
First Decision by Editorial Office Director
Return for Revision	2016-05-18 11:36
Revised	2016-06-29 00:00
Publication Fee Transferred
Second Decision by Editor	2016-07-12 13:02
Second Decision by Editor-in-Chief	2016-07-12 17:10
Final Decision by Editorial Office Director	2016-07-22 12:14
Articles in Press	2016-07-22 12:14
Edit the Manuscript by Language Editor	2016-07-30 08:32
Typeset the Manuscript	2016-09-12 19:40
Publish the Manuscript Online	2016-09-14 11:03

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Infectious Diseases
Manuscript Type	Letter to the Editor
Article Title	Predictive potential of <i>IL-28B</i> genetic testing for interferon based hepatitis C virus therapy in Pakistan: Current scenario and future perspective
Manuscript Source	Unsolicited Manuscript
All Author List	Muhammad Sohail Afzal
Funding Agency and Grant Number
Corresponding Author	Muhammad Sohail Afzal, PhD, Department of Chemistry, School of Science, University of Management and Technology, C-Ⅱ Johar Town, Lahore 54000, Pakistan. sohail.ncvi@gmail.com
Key Words	Diagnostics; Hepatitis C virus; Interferon therapy; Polymorphisms; <i>IL-28B</i>; Genetic testing; Pakistan
Core Tip	Pakistan has a very heavy burden of hepatitis C virus (HCV) infection with around 11 million positive cases; however, in spite of well established prognostic value, the data regarding the role of interleukin 28B (<i>IL-28B</i>) single nucleotide polymorphisms (SNPs) in HCV antiviral therapy response are very limited. There are only six reports on the topic and it can be concluded from this limited information that <i>IL-28B</i> could be a good prognosis marker for HCV patient management in Pakistan. The major prevalent HCV genotype in Pakistan is 3a and <i>IL-28B</i> SNP rs12979860 showed a good prediction for interferon based antiviral therapy response against this viral genotype. It can be pre-dicted that inclusion of <i>IL-28B</i> genetic testing in routine diagnostic set-up of Pakistan will help in better management of the disease. A well directed antiviral therapy based on personalized <i>IL-28B</i> genotyping along with virus genotyping will help in lessening of therapy cost and better management of the disease.
Publish Date	2016-09-14 11:03
Citation	Afzal MS. Predictive potential of IL-28B genetic testing for interferon based hepatitis C virus therapy in Pakistan: Current scenario and future perspective. World J Hepatol 2016; 8(26): 1116-1118
URL	http://www.wjgnet.com/1948-5182/full/v8/i26/1116.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i26.1116

Full Article (PDF)	WJH-8-1116.pdf
Full Article (Word)	WJH-8-1116.doc
Manuscript File	26349-Review.doc
Answering Reviewers	26349-Answering reviewers.pdf
Audio Core Tip	26349-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	26349-Conflict-of-interest statement.pdf
Copyright License Agreement	26349-Copyright assignment.pdf
Peer-review Report	26349-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	26349-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	26349-Scientific misconduct check.pdf
Scientific Editor Work List	26349-Scientific editor work list.pdf