Publication Name	World Journal of Gastroenterology
Manuscript ID	26360
Country	Japan

Received	2016-04-06 08:42
Peer-Review Started	2016-04-06 11:31
To Make the First Decision	2016-05-12 10:27
Return for Revision	2016-05-18 09:34
Revised	2016-05-24 14:52
Second Decision	2016-06-02 10:15
Accepted by Journal Editor-in-Chief	2016-06-02 20:05
Accepted by Executive Editor-in-Chief	2016-06-13 18:11
Articles in Press	2016-06-13 18:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-07-13 18:29
Publish the Manuscript Online	2016-07-22 13:48

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	c-Jun N-terminal kinase-mediated Rubicon expression enhances hepatocyte lipoapoptosis and promotes hepatocyte ballooning
Manuscript Source	Invited Manuscript
All Author List	Akiko Suzuki, Keisuke Kakisaka, Yuji Suzuki, Ting Wang and Yasuhiro Takikawa
Funding Agency and Grant Number	Funding Agency Grant Number KAKENHI Grant 16K21307
Corresponding Author	Keisuke Kakisaka, MD, PhD, Assistant Professor, Division of Hepatology, Department of Internal Medicine, Iwate Medical University, 19-1 Uchimaru, Iwate, Morioka 0208505, Japan. keikaki@iwate-med.ac.jp
Key Words	Ballooned hepatocyte; Caspase 9; c-Jun N-terminal kinase; Rubicon; SP600125
Core Tip	Autophagy is interrupted in both in vivo and in vitro non-alcoholic steatohepatitis (NASH) models, and impaired autophagy is mediated by Run domain Beclin-1 interacting and cysteine-rich containing (Rubicon) protein expression via c-Jun N-terminal kinase phosphorylation. Rubicon expression appears prior to apoptosis and enhances palmitate toxicity in the hepatocytes, and caspase-9 decreases Rubicon at the protein level during lipoapoptosis. Caspase-9 inhibition with Rubicon expression induces both hepatocyte enlargement and endoplasmic reticulum stress accumulation. The present study extends our knowledge on the precise balance between lipoapoptosis and autophagy via Rubicon expression in NASH and reveals a possible pathophysiology of ballooned hepatocytes in NASH.
Publish Date	2016-07-22 13:48
Citation	Suzuki A, Kakisaka K, Suzuki Y, Wang T, Takikawa Y. c-Jun N-terminal kinase-mediated Rubicon expression enhances hepatocyte lipoapoptosis and promotes hepatocyte ballooning. World J Gastroenterol 2016; 22(28): 6509-6519
URL	http://www.wjgnet.com/1007-9327/full/v22/i28/6509.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i28.6509

Full Article (PDF)	WJG-22-6509.pdf
Full Article (Word)	WJG-22-6509.doc
Manuscript File	26360-Review.docx
Answering Reviewers	26360-Answering review(s).pdf
Audio Core Tip	26360-Audio core tip.mp3
Biostatistics Review Certificate	26360-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	26360-Conflict-of-interest statement.pdf
Copyright License Agreement	26360-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	26360-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	26360-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	26360-Language certificate.pdf
Peer-review Report	26360-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	26360-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	26360-Scientific misconduct check.pdf
Scientific Editor Work List	26360-Scientific editor work list.pdf