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7/22/2016 1:36:00 PM | Browse: 719 | Download: 1035
Publication Name World Journal of Gastroenterology
Manuscript ID 26360
Country/Territory Japan
Received
2016-04-06 08:42
Peer-Review Started
2016-04-06 11:31
To Make the First Decision
2016-05-12 10:27
Return for Revision
2016-05-18 09:34
Revised
2016-05-24 14:52
Second Decision
2016-06-02 10:15
Accepted by Journal Editor-in-Chief
2016-06-02 20:05
Accepted by Company Editor-in-Chief
2016-06-13 18:11
Articles in Press
2016-06-13 18:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-07-13 18:29
Publish the Manuscript Online
2016-07-22 13:48
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title c-Jun N-terminal kinase-mediated Rubicon expression enhances hepatocyte lipoapoptosis and promotes hepatocyte ballooning
Manuscript Source Invited Manuscript
All Author List Akiko Suzuki, Keisuke Kakisaka, Yuji Suzuki, Ting Wang and Yasuhiro Takikawa
Funding Agency and Grant Number
Funding Agency Grant Number
KAKENHI Grant 16K21307
Corresponding Author Keisuke Kakisaka, MD, PhD, Assistant Professor, Division of Hepatology, Department of Internal Medicine, Iwate Medical University, 19-1 Uchimaru, Iwate, Morioka 0208505, Japan. keikaki@iwate-med.ac.jp
Key Words Ballooned hepatocyte; Caspase 9; c-Jun N-terminal kinase; Rubicon; SP600125
Core Tip Autophagy is interrupted in both in vivo and in vitro non-alcoholic steatohepatitis (NASH) models, and impaired autophagy is mediated by Run domain Beclin-1 interacting and cysteine-rich containing (Rubicon) protein expression via c-Jun N-terminal kinase phosphorylation. Rubicon expression appears prior to apoptosis and enhances palmitate toxicity in the hepatocytes, and caspase-9 decreases Rubicon at the protein level during lipoapoptosis. Caspase-9 inhibition with Rubicon expression induces both hepatocyte enlargement and endoplasmic reticulum stress accumulation. The present study extends our knowledge on the precise balance between lipoapoptosis and autophagy via Rubicon expression in NASH and reveals a possible pathophysiology of ballooned hepatocytes in NASH.
Publish Date 2016-07-22 13:48
Citation Suzuki A, Kakisaka K, Suzuki Y, Wang T, Takikawa Y. c-Jun N-terminal kinase-mediated Rubicon expression enhances hepatocyte lipoapoptosis and promotes hepatocyte ballooning. World J Gastroenterol 2016; 22(28): 6509-6519
URL http://www.wjgnet.com/1007-9327/full/v22/i28/6509.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i28.6509
Full Article (PDF) WJG-22-6509.pdf
Full Article (Word) WJG-22-6509.doc
Manuscript File 26360-Review.docx
Answering Reviewers 26360-Answering review(s).pdf
Audio Core Tip 26360-Audio core tip.mp3
Biostatistics Review Certificate 26360-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 26360-Conflict-of-interest statement.pdf
Copyright License Agreement 26360-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 26360-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 26360-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 26360-Language certificate.pdf
Peer-review Report 26360-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 26360-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 26360-Scientific misconduct check.pdf
Scientific Editor Work List 26360-Scientific editor work list.pdf