Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	26374
Country	Australia

Received	2016-04-06 16:41
Peer-Review Started	2016-04-07 10:56
To Make the First Decision	2016-06-06 17:26
Return for Revision	2016-06-07 14:22
Revised	2016-07-16 06:50
Second Decision	2016-07-27 15:25
Accepted by Journal Editor-in-Chief	2016-07-28 01:04
Accepted by Executive Editor-in-Chief	2016-08-08 14:55
Articles in Press	2016-08-08 14:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-10-24 14:26
Publish the Manuscript Online	2016-10-31 09:01

ISSN	2150-5349 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Genetics & Heredity
Manuscript Type	Minireviews
Article Title	Widespread use of gastric acid inhibitors in infants: Are they needed? Are they safe?
Manuscript Source	Invited Manuscript
All Author List	Mark Safe, Wei H Chan, Steven T Leach, Lee Sutton, Kei Lui and Usha Krishnan
Funding Agency and Grant Number
Corresponding Author	Dr. Usha Krishnan, Department of Paediatric Gastroenterology, Sydney Children’s Hospital, High Street, Randwick NSW 2031, Australia. usha.krishnan@sesiahs.health.nsw.gov.au
Key Words	Gastroesophageal reflux; Infants; Proton pump inhibitors; Ranitidine; Safety; Adverse events
Core Tip	Gastroesophageal reflux is a common phenomenon in infants, but the differentiation between gastroesophageal reflux and gastroesophageal reflux disease can be difficult. Symptoms are non-specific and there is increasing evidence that the majority of symptoms may not be acid-related. Despite this, gastric acid inhibitors such as proton pump inhibitors are widely and increasingly used, often without objective evidence or investigations to guide treatment. Several studies have shown that these medications are ineffective at treating symptoms associated with reflux in the absence of endoscopically proven oesophagitis. With a lack of evidence for efficacy, attention is now being turned to the potential risks of gastric acid suppression. Previously assumed safety of these medications is being challenged with evidence of potential side effects including GI and respiratory infections, bacterial overgrowth, adverse bone health, food allergy and drug interactions.
Publish Date	2016-10-31 09:01
Citation	Safe M, Chan WH, Leach ST, Sutton L, Lui K, Krishnan U. Widespread use of gastric acid inhibitors in infants: Are they needed? Are they safe? World J Gastrointest Pharmacol Ther 2016; 7(4): 531-539
URL	http://www.wjgnet.com/2150-5349/full/v7/i4/531.htm
DOI	http://dx.doi.org/10.4292/wjgpt.v7.i4.531

Full Article (PDF)	WJGPT-7-531.pdf
Full Article (Word)	WJGPT-7-531.doc
Manuscript File	26374-Review.docx
Answering Reviewers	26374-Answering reviewers.pdf
Audio Core Tip	26374-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	26374-Conflict-of-interest statement.pdf
Copyright License Agreement	26374-Copyright assignment.pdf
Peer-review Report	26374-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	26374-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	26374-Scientific misconduct check.pdf
Scientific Editor Work List	26374-Scientific editor work list.pdf