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10/31/2016 9:01:00 AM | Browse: 307 | Download: 401
Publication Name World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID 26374
Country of Manuscript Source Australia
2016-04-06 16:41
Peer-Review Started
2016-04-07 10:56
To Make the First Decision
2016-06-06 17:26
Return for Revision
2016-06-07 14:22
2016-07-16 06:50
Second Decision
2016-07-27 15:25
Accepted by Journal Editor-in-Chief
2016-07-28 01:04
Accepted by Company Editor-in-Chief
2016-08-08 14:55
Articles in Press
2016-08-08 14:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-10-24 14:26
Publish the Manuscript Online
2016-10-31 09:01
ISSN 2150-5349 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Genetics and Heredity
Manuscript type Minireviews
Article Title Widespread use of gastric acid inhibitors in infants: Are they needed? Are they safe?
Manuscript Source Invited Manuscript
All Author List Mark Safe, Wei H Chan, Steven T Leach, Lee Sutton, Kei Lui and Usha Krishnan
Funding Agency and Grant Number
Correspondence To Dr. Usha Krishnan, Department of Paediatric Gastroenterology, Sydney Children’s Hospital, High Street, Randwick NSW 2031, Australia. usha.krishnan@sesiahs.health.nsw.gov.au
Keywords Gastroesophageal reflux; Infants; Proton pump inhibitors; Ranitidine; Safety; Adverse events
Core Tip Gastroesophageal reflux is a common phenomenon in infants, but the differentiation between gastroesophageal reflux and gastroesophageal reflux disease can be difficult. Symptoms are non-specific and there is increasing evidence that the majority of symptoms may not be acid-related. Despite this, gastric acid inhibitors such as proton pump inhibitors are widely and increasingly used, often without objective evidence or investigations to guide treatment. Several studies have shown that these medications are ineffective at treating symptoms associated with reflux in the absence of endoscopically proven oesophagitis. With a lack of evidence for efficacy, attention is now being turned to the potential risks of gastric acid suppression. Previously assumed safety of these medications is being challenged with evidence of potential side effects including GI and respiratory infections, bacterial overgrowth, adverse bone health, food allergy and drug interactions.
Publish Date 2016-10-31 09:01
Citation Safe M, Chan WH, Leach ST, Sutton L, Lui K, Krishnan U. Widespread use of gastric acid inhibitors in infants: Are they needed? Are they safe? World J Gastrointest Pharmacol Ther 2016; 7(4): 531-539
Url http://www.wjgnet.com/2150-5349/full/v7/i4/531.htm
DOI http://dx.doi.org/10.4292/wjgpt.v7.i4.531
Full Article (PDF) WJGPT-7-531.pdf
Full Article (Word) WJGPT-7-531.doc
Manuscript File 26374-Review.docx
Answering Reviewers 26374-Answering reviewers.pdf
Audio Core Tip 26374-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 26374-Conflict-of-interest statement.pdf
Copyright License Agreement 26374-Copyright assignment.pdf
Peer-review Report 26374-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 26374-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 26374-Scientific misconduct check.pdf
Scientific Editor Work List 26374-Scientific editor work list.pdf