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8/15/2016 10:30:00 AM | Browse: 482 | Download: 449
Publication Name World Journal of Gastroenterology
Manuscript ID 26383
Country of Manuscript Source United States
Received
2016-04-07 08:58
Peer-Review Started
2016-04-07 10:10
To Make the First Decision
2016-05-12 10:27
Return for Revision
2016-05-26 14:23
Revised
2016-06-02 00:00
Second Decision
2016-06-20 08:17
Accepted by Journal Editor-in-Chief
2016-06-20 18:16
Accepted by Company Editor-in-Chief
2016-06-28 15:52
Articles in Press
2016-06-28 15:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-08-04 15:21
Publish the Manuscript Online
2016-08-15 10:30
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Editorial
Article Title Mitochondrial DNA from hepatocytes as a ligand for TLR9: Drivers of nonalcoholic steatohepatitis?
Manuscript Source Invited Manuscript
All Author List Priya Handa, Akhila Vemulakonda, Kris V Kowdley, Misael Uribe and Nahum Méndez-Sánchez
Funding Agency and Grant Number
Corresponding author Priya Handa, MS, PhD, Senior Research Scientist, Organ Care Research and Liver Care Network, 1124 Columbia Street, Suite 600, Swedish Medical Center, Seattle, WA 98104, United States. priya.handa@swedish.org
Keywords TLR9; Damage-associated molecular patterns; Products of microbial metabolism produced by pathogens; Mitochondrial DNA; Hepatocytes; Nonalcoholic steatohepatitis; Nonalcoholic fatty liver disease; Inflammation; Innate immune signaling; Kupffer cells; Therapy
Core Tip Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease. It has been shown that innate immune activation contributes to the progression of NAFLD by inducing hepatic inflammation. A new study recently demonstrated that hepatocyte mitochondrial DNA acts as a damage -induced molecular pattern activating hepatic TLR9 to initiate and amplify inflammatory signaling leading to nonalcoholic steatohepatitis (NASH). Inhibiting TLR9 by using a synthetic antagonist, IRS 954, reversed steatohepatitis; as did a whole body ablation of TLR9 or a myeloid-specific knockout of TLR9. This editorial summarizes the findings of the new study and describes potential novel therapeutic targets that may hold promise for NASH treatment.
Publish Date 2016-08-15 10:30
Citation Handa P, Vemulakonda A, Kowdley KV, Uribe M, Mendez-Sanchez N. Mitochondrial DNA from hepatocytes as a ligand for TLR9: Drivers of nonalcoholic steatohepatitis? World J Gastroenterol 2016; 22(31): 6965-6971
Url http://www.wjgnet.com/1007-9327/full/v22/i31/6965.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i31.6965
Full Article (PDF) WJG-22-6965.pdf
Full Article (Word) WJG-22-6965.doc
Manuscript File 26383-Review.docx
Answering Reviewers 26383-Answering reviewers.pdf
Audio Core Tip 26383-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 26383-Conflict-of-interest statement.pdf
Copyright License Agreement 26383-Copyright assignment.pdf
Peer-review Report 26383-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 26383-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 26383-Scientific misconduct check.pdf
Scientific Editor Work List 26383-Scientific editor work list.pdf