| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Reversal of multidrug resistance of hepatocellular carcinoma cells by metformin through inhibiting NF-κB gene transcription
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wei Wu, Jun-Ling Yang, Yi-Lang Wang, Han Wang, Min Yao, Li Wang, Juan-Juan Gu, Yin Cai, Yun Shi and Deng-Fu Yao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Projects of Jiangsu Elitist Peak in Six Fields |
2013-WSN-078 |
| Projects of Jiangsu Elitist Peak in Six Fields |
2013-WSW-011 |
| Projects of Jiangsu Elitist Peak in Six Fields |
2014-YY-028 |
| QingLan Program of Jiangsu Higher Education |
|
| Youth Science Foundation of Nantong Health Department |
WQ2014005 |
| International Science & Technology Cooperation Program |
2013DFA32150 |
|
| Corresponding Author |
Deng-Fu Yao, MD, PhD, Professor, Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, No. 20 West Temple Road, Nantong 226001, Jiangsu Province, China. yaodf@ahnmc.com |
| Key Words |
Metformin; Reversal; Multidrug resistance; Hepatocellular carcinoma |
| Core Tip |
Metformin might target AMP-activated protein kinase mammalian target of rapamycin pathway, suppress hypoxia?inducible factor-1α and transcriptionally down-regulate P-glycoprotein (P-gp) and multidrug resistance (MDR)-associated protein 1, suggesting that metformin may reverse MDR by targeting the AMP-activated protein kinase/mammalian target of rapamycin/hypoxia-inducible factor-1α/P-gp and MDR-associated protein 1 pathways. In the present study, HepG2/ADM cells pretreated with metformin were sensitized to doxorubicin and P-gp was decreased through the nuclear factor-κB (NF-κB) signaling pathway. The synergistic effects were found in the cells with regard to proliferation inhibition, cell cycle arrest and inducing apoptosis, and inhibiting P-gp expression via the NF-κB signaling pathway effectively reversed MDR by down-regulating MDR1/P-gp expression. |
| Publish Date |
2016-08-17 08:44 |
| Citation |
Wu W, Yang JL, Wang YL, Wang H, Yao M, Wang L, Gu JJ, Cai Y, Shi Y, Yao DF. Reversal of multidrug resistance of hepatocellular carcinoma cells by metformin through inhibiting NF-κB gene transcription. World J Hepatol 2016; 8(23): 985-993 |
| URL |
http://www.wjgnet.com/1948-5182/full/v8/i23/985.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v8.i23.985 |
