Publication Name	World Journal of Gastroenterology
Manuscript ID	26444
Country	China

Received	2016-04-10 11:19
Peer-Review Started	2016-04-10 18:59
To Make the First Decision	2016-05-12 10:26
Return for Revision	2016-05-12 10:59
Revised	2016-06-10 17:52
Second Decision	2016-06-20 08:18
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-06-28 15:54
Articles in Press	2016-06-28 15:54
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-07-05 03:01
Typeset the Manuscript	2016-08-04 17:22
Publish the Manuscript Online	2016-08-15 10:30

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Therapeutic potential of targeting acinar cell reprogramming in pancreatic cancer
Manuscript Source	Invited Manuscript
All Author List	Chi-Hin Wong, You-Jia Li and Yang-Chao Chen
Funding Agency and Grant Number	Funding Agency Grant Number General Research Fund, Research Grants Council of Hong Kong CUHK462211 General Research Fund, Research Grants Council of Hong Kong CUHK462713 General Research Fund, Research Grants Council of Hong Kong 14102714 National Natural Science Foundation of China 81101888 National Natural Science Foundation of China 8142730
Corresponding Author	Yang-Chao Chen, PhD, Associate Professor, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China. b110796@mailserv.cuhk.edu.hk
Key Words	Acinar cells; Acinar-to-ductal metaplasia; Pancreatic ductal adenocarcinoma; Signal transduction; Reprogramming
Core Tip	Treating pancreatic ductal adenocarcinoma (PDAC) remains challenging due to the lack of effec-tive therapeutics. Apart from pancreatic duct cells, acinar cells may also be the origin of PDAC. During pancreatitis or combined with activating KRasG12D mutation, acinar cells undergo a transdifferentiation process called acinar-to-ductal-metaplasia (ADM), forming duct cells which may then be transformed into PanIN and eventually PDAC. This process involves MAPK, Wnt, Notch and PI3K/Akt signaling. Since ADM may be a reversible process, switching PDAC back to normal cells may also be achieved and developed as a novel therapy.
Publish Date	2016-08-15 10:30
Citation	Wong CH, Li YJ, Chen YC. Therapeutic potential of targeting acinar cell reprogramming in pancreatic cancer. World J Gastroenterol 2016; 22(31): 7046-7057
URL	http://www.wjgnet.com/1007-9327/full/v22/i31/7046.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i31.7046

Full Article (PDF)	WJG-22-7046.pdf
Full Article (Word)	WJG-22-7046.doc
Manuscript File	26444-Review.docx
Answering Reviewers	26444-Answering reviewers.pdf
Audio Core Tip	26444-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	26444-Conflict-of-interest statement.pdf
Copyright License Agreement	26444-Copyright assignment.pdf
Peer-review Report	26444-Peer-review(s).pdf
Scientific Misconduct Check	26444-Scientific misconduct check.pdf
Scientific Editor Work List	26444-Scientific editor work list.pdf