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Articles Published Processes
11/10/2016 9:27:00 AM | Browse: 1183 | Download: 1925
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Received |
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2016-04-10 10:17 |
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Peer-Review Started |
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2016-04-12 09:25 |
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To Make the First Decision |
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2016-05-17 12:03 |
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Return for Revision |
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2016-05-19 19:15 |
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Revised |
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2016-06-01 10:24 |
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Second Decision |
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2016-08-12 13:55 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-08-31 12:12 |
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Articles in Press |
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2016-08-31 12:12 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-11-03 15:08 |
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Publish the Manuscript Online |
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2016-11-10 09:27 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Implanting 1.1B4 human β-cell pseudoislets improves glycaemic control in diabetic severe combined immune deficient mice
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Alastair D Green, Srividya Vasu, Neville H McClenaghan and Peter R Flatt |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| University of Ulster Research Strategic funding |
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| The award of a Northern Ireland Department of Employment and Learning research studentship |
To Alastair D Green |
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| Corresponding Author |
Srividya Vasu, PhD, Visiting Fellow, Cell Growth and Metabolism Section, National Institute for Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Old Georgetown Road and Center Drive, Bethesda, MD 20892, United States. s.vasu@outlook.com |
| Key Words |
Human β-cell line; 1.1B4; Cell therapy; Insulin; Pseudoislets |
| Core Tip |
Human insulin-releasing 1.1B4 β-cell suspensions and psuedoislets were implanted in streptozotocin-diabetic severe combined immune deficient mice to assess their antidiabetic potential. Both cell configurations yielded vascularised, insulin positive β-cell masses. These were associated with beneficial effects on hyperphagia, polydipsia, body weight, hypoinsulinaemia, hyperglycaemia and glucose tolerance. Both treatments were also associated with significant improvements in islet morphology and increased β:β-cell ratio. Pseudoislet recipients displayed gradual glucose normalization, while cell suspension recipients ultimately presented with hypoglycaemic complications. These results provide proof of concept for possible clinical artificial human β-cell psuedoislets, although further work is needed to address the tumourigenicity of clonal cell-lines. |
| Publish Date |
2016-11-10 09:27 |
| Citation |
Green AD, Vasu S, McClenaghan NH, Flatt PR. Implanting 1.1B4 human β-cell pseudoislets improves glycaemic control in diabetic severe combined immune deficient mice. World J Diabetes 2016; 7(19): 523-533 |
| URL |
http://www.wjgnet.com/1948-9358/full/v7/i19/523.htm |
| DOI |
http://dx.doi.org/10.4239/wjd.v7.i19.523 |
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