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11/10/2016 9:27:00 AM | Browse: 441 | Download: 536
Publication Name World Journal of Diabetes
Manuscript ID 26452
Country/Territory United Kingdom
2016-04-10 10:17
Peer-Review Started
2016-04-12 09:25
To Make the First Decision
2016-05-17 12:03
Return for Revision
2016-05-19 19:15
2016-06-01 10:24
Second Decision
2016-08-12 13:55
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-08-31 12:12
Articles in Press
2016-08-31 12:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-11-03 15:08
Publish the Manuscript Online
2016-11-10 09:27
ISSN 1948-9358 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Endocrinology and Metabolism
Manuscript Type Basic Study
Article Title Implanting 1.1B4 human β-cell pseudoislets improves glycaemic control in diabetic severe combined immune deficient mice
Manuscript Source Invited Manuscript
All Author List Alastair D Green, Srividya Vasu, Neville H McClenaghan and Peter R Flatt
Funding Agency and Grant Number
Funding Agency Grant Number
University of Ulster Research Strategic funding
The award of a Northern Ireland Department of Employment and Learning research studentship To Alastair D Green
Corresponding author Srividya Vasu, PhD, Visiting Fellow, Cell Growth and Metabolism Section, National Institute for Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Old Georgetown Road and Center Drive, Bethesda, MD 20892, United States. s.vasu@outlook.com
Keywords Human β-cell line; 1.1B4; Cell therapy; Insulin; Pseudoislets
Core Tip Human insulin-releasing 1.1B4 β-cell suspensions and psuedoislets were implanted in streptozotocin-diabetic severe combined immune deficient mice to assess their antidiabetic potential. Both cell configurations yielded vascularised, insulin positive β-cell masses. These were associated with beneficial effects on hyperphagia, polydipsia, body weight, hypoinsulinaemia, hyperglycaemia and glucose tolerance. Both treatments were also associated with significant improvements in islet morphology and increased β:β-cell ratio. Pseudoislet recipients displayed gradual glucose normalization, while cell suspension recipients ultimately presented with hypoglycaemic complications. These results provide proof of concept for possible clinical artificial human β-cell psuedoislets, although further work is needed to address the tumourigenicity of clonal cell-lines.
Publish Date 2016-11-10 09:27
Citation Green AD, Vasu S, McClenaghan NH, Flatt PR. Implanting 1.1B4 human β-cell pseudoislets improves glycaemic control in diabetic severe combined immune deficient mice. World J Diabetes 2016; 7(19): 523-533
Url http://www.wjgnet.com/1948-9358/full/v7/i19/523.htm
DOI http://dx.doi.org/10.4239/wjd.v7.i19.523
Full Article (PDF) WJD-7-523.pdf
Full Article (Word) WJD-7-523.doc
Manuscript File 26452-Review.docx
Answering Reviewers 26452-Answering reviewers.pdf
Audio Core Tip 26452-Audio core tip.mp3
Biostatistics Review Certificate 26452-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 26452-Conflict-of-interest statement.pdf
Copyright License Agreement 26452-Copyright assignment.pdf
Data Sharing Statement 26452-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 26452-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 26452-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 26452-Institutional review board statement.pdf
Peer-review Report 26452-Peer-review(s).pdf
Scientific Misconduct Check 26452-Scientific misconduct check.pdf
Scientific Editor Work List 26452-Scientific editor work list.pdf