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Articles Published Processes
9/30/2016 5:59:00 PM | Browse: 1388 | Download: 2526
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Received |
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2016-04-11 10:39 |
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Peer-Review Started |
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2016-04-13 16:24 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2016-06-20 15:02 |
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Revised |
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2016-07-07 13:50 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2016-08-01 19:25 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2016-08-08 17:33 |
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Articles in Press |
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2016-08-08 17:33 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-09-26 08:18 |
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Publish the Manuscript Online |
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2016-09-30 18:06 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Integrative & Complementary Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Rhubarb extract partially improves mucosal integrity in chemotherapy-induced intestinal mucositis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Juliana E Bajic, Georgina L Eden, Lorrinne S Lampton, Ker Y Cheah, Kerry A Lymn, Jinxin V Pei, Andrea J Yool and Gordon S Howarth |
| Funding Agency and Grant Number |
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| Corresponding Author |
Juliana E Bajic, BHSc (Hons), Discipline of Physiology, Faculty of Health Sciences, School of Medicine, The University of Adelaide, Frome Road, Adelaide 5005, Australia. juliana.bajic@adelaide.edu.au
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| Key Words |
Fluorouracil; Inflammation; Mucositis; Rats; Rheum |
| Core Tip |
Aqueous rhubarb extract partially improved selected parameters of 5-fluorouracil (5-FU)-induced intestinal mucositis in rats. Exposure to 5-FU decreased bodyweight, yet high-dose rhubarb extract (RE) and low-dose RE (ldr) showed no changes. myeloperoxidase activity was significantly decreased in rats treated with LDR and 5-FU when compared to the intestinal mucositis control group. Ileal mucosal thickness was significantly improved (19%) in animals with intestinal mucositis and treated with LDR. In xenopus oocytes expressing AQP4 water channels, RE blocked swelling induced by a decrease in external osmotic pressure which indicated that water influx across the epithelial barrier was selectively blocked by RE.
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| Publish Date |
2016-09-30 18:06 |
| Citation |
Bajic JE, Eden GL, Lampton LS, Cheah KY, Lymn KA, Pei JV, Yool AJ, Howarth GS. Rhubarb extract partially improves mucosal integrity in chemotherapy-induced intestinal mucositis. World J Gastroenterol 2016; 22(37): 8322-8333 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i37/8322.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i37.8322 |
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