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9/30/2016 5:59:00 PM | Browse: 492 | Download: 518
Publication Name World Journal of Gastroenterology
Manuscript ID 26476
Country/Territory Australia
Received
2016-04-11 10:39
Peer-Review Started
2016-04-13 16:24
To Make the First Decision
2016-06-20 09:03
Return for Revision
2016-06-20 15:02
Revised
2016-07-07 13:50
Second Decision
2016-08-01 19:25
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-08-08 17:33
Articles in Press
2016-08-08 17:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-09-26 08:18
Publish the Manuscript Online
2016-09-30 18:06
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Integrative and Complementary Medicine
Manuscript Type Basic Study
Article Title Rhubarb extract partially improves mucosal integrity in chemotherapy-induced intestinal mucositis
Manuscript Source Invited Manuscript
All Author List Juliana E Bajic, Georgina L Eden, Lorrinne S Lampton, Ker Y Cheah, Kerry A Lymn, Jinxin V Pei, Andrea J Yool and Gordon S Howarth
Funding Agency and Grant Number
Corresponding author Juliana E Bajic, BHSc (Hons), Discipline of Physiology, Faculty of Health Sciences, School of Medicine, The University of Adelaide, Frome Road, Adelaide 5005, Australia. juliana.bajic@adelaide.edu.au
Keywords Fluorouracil; Inflammation; Mucositis; Rats; Rheum
Core Tip Aqueous rhubarb extract partially improved selected parameters of 5-fluorouracil (5-FU)-induced intestinal mucositis in rats. Exposure to 5-FU decreased bodyweight, yet high-dose rhubarb extract (RE) and low-dose RE (ldr) showed no changes. myeloperoxidase activity was significantly decreased in rats treated with LDR and 5-FU when compared to the intestinal mucositis control group. Ileal mucosal thickness was significantly improved (19%) in animals with intestinal mucositis and treated with LDR. In xenopus oocytes expressing AQP4 water channels, RE blocked swelling induced by a decrease in external osmotic pressure which indicated that water influx across the epithelial barrier was selectively blocked by RE.
Publish Date 2016-09-30 18:06
Citation Bajic JE, Eden GL, Lampton LS, Cheah KY, Lymn KA, Pei JV, Yool AJ, Howarth GS. Rhubarb extract partially improves mucosal integrity in chemotherapy-induced intestinal mucositis. World J Gastroenterol 2016; 22(37): 8322-8333
Url http://www.wjgnet.com/1007-9327/full/v22/i37/8322.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i37.8322
Full Article (PDF) WJG-22-8322.pdf
Full Article (Word) WJG-22-8322.doc
Manuscript File 26476-Review.docx
Answering Reviewers 26476-Answering reviewers.pdf
Audio Core Tip 26476-Audio core tip.wav
Conflict-of-Interest Disclosure Form 26476-Conflict-of-interest statement.pdf
Copyright License Agreement 26476-Copyright assignment.pdf
Data Sharing Statement 26476-Data sharing statement.pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20160411095838.docx
Institutional Animal Care and Use Committee Approval Form or Document 26476-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 26476-Institutional review board statement.pdf
Peer-review Report 26476-Peer-review(s).pdf
Scientific Misconduct Check 26476-Scientific misconduct check.pdf
Scientific Editor Work List 26476-Scientific editor work list.pdf