Publication Name	World Journal of Cardiology
Manuscript ID	26520
Country	Japan

Received	2016-05-26 09:50
Peer-Review Started	2016-05-26 10:34
To Make the First Decision	2016-06-12 09:14
Return for Revision	2016-06-16 10:36
Revised	2016-06-22 13:53
Second Decision	2016-07-05 17:39
Accepted by Journal Editor-in-Chief	2016-07-06 14:18
Accepted by Executive Editor-in-Chief	2016-07-18 10:44
Articles in Press	2016-07-18 10:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-08-10 14:20
Publish the Manuscript Online	2016-08-22 14:58

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Observational Study
Article Title	Relationship between coronary calcium score and high-risk plaque/significant stenosis
Manuscript Source	Invited Manuscript
All Author List	Kohichiro Iwasaki and Takeshi Matsumoto
Funding Agency and Grant Number
Corresponding Author	Kohichiro Iwasaki, MD, Department of Cardiology, Okayama Kyokuto Hospital, 567-1, Kurata, Naka-ku, Okayama 703-8265, Japan. kiwasaki@kyokuto.or.jp
Key Words	Coronary calcium score; Coronary stenosis; High-risk plaque; Low attenuation plaque; Napkin-ring sign; Positive remodeling; Spotty calcification
Core Tip	Coronary computed tomographic angiography was performed in 651 patients and these patients were divided into the four groups according to coronary calcium score (CCS): 0, 1-100, 101-400 and > 400. The incidence of high-risk plaque was not significantly different among the three groups, except patients with zero CCS. The incidence of significant stenosis increased stepwise as CCS increased, as did the rate of major coronary event. Therefore, the stepwise increased risk of coronary events associated with increasing CCS is caused by an increasing incidence of significant stenosis, while that of high-risk plaque remains the same.
Publish Date	2016-08-22 14:58
Citation	Iwasaki K, Matsumoto T. Relationship between coronary calcium score and high-risk plaque/significant stenosis. World J Cardiol 2016; 8(8): 481-487
URL	http://www.wjgnet.com/1949-8462/full/v8/i8/481.htm
DOI	http://dx.doi.org/10.4330/wjc.v8.i8.481

Full Article (PDF)	WJC-8-481.pdf
Full Article (Word)	WJC-8-481.doc
Manuscript File	26520-Review.doc
Answering Reviewers	26520-Answering reviewers.pdf
Audio Core Tip	26520-Audio core tip.m4a
Biostatistics Review Certificate	26520-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	26520-Conflict-of-interest statement.pdf
Copyright License Agreement	26520-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20160525154754.pdf
Institutional Review Board Approval Form or Document	26520-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	26520-Language certificate.pdf
Peer-review Report	26520-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	26520-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	26520-Scientific misconduct check.pdf
Scientific Editor Work List	26520-Scientific editor work list.pdf