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Articles Published Processes
8/15/2016 10:30:00 AM | Browse: 852 | Download: 1401
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Received |
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2016-04-20 14:56 |
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Peer-Review Started |
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2016-04-21 10:12 |
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To Make the First Decision |
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2016-05-27 14:57 |
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Return for Revision |
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2016-05-28 13:31 |
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Revised |
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2016-06-09 22:53 |
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Second Decision |
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2016-06-28 09:06 |
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Accepted by Journal Editor-in-Chief |
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2016-06-28 15:16 |
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Accepted by Executive Editor-in-Chief |
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2016-07-06 18:31 |
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Articles in Press |
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2016-07-06 18:31 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-08-06 17:54 |
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Publish the Manuscript Online |
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2016-08-15 10:30 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Comparative effects of α2δ-1 ligands in mouse models of colonic hypersensitivity
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Mathieu Meleine, Ludivine Boudieu, Agathe Gelot, Emilie Muller, Amandine Lashermes, Julien Matricon, Celine Silberberg, Vassilia Theodorou, Alain Eschalier, Denis Ardid and Frederic A Carvalho |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| ANR VISCERALGY |
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| Corresponding Author |
Frederic A Carvalho, PhD, Université d’Auvergne, INSERM 1107 Neuro-Dol, 28 Place Henri Dunant, BP 38, F-63001 Clermont-Ferrand,
France. frederic.carvalho@inserm.fr |
| Key Words |
Neonatal maternal separation; Dextran sulfate sodium; Colonic hypersensitivity mouse models; Colorectal distension; α2δ-1 ligands |
| Core Tip |
Chronic abdominal pain is commonly re-ported by patients suffering from gastrointestinal disorders. These patients form a very heterogeneous group in regards to their colonic inflammation status. Such heterogeneity may explain the current lack of satisfactory options regarding pain management in these patients. This preclinical study shows that α2δ-1 ligands are effective against colonic hypersensitivity, especially when they are used in the case of moderate intestinal inflammation. Thus, our results pointed out the need for assessing the clinical benefits of α2δ-1 ligands on chronic abdominal pain based on the level of intestinal inflammation observed in patients. |
| Publish Date |
2016-08-15 10:30 |
| Citation |
Meleine M, Boudieu L, Gelot A, Muller E, Lashermes A, Matricon J, Silberberg C, Theodorou V, Eschalier A, Ardid D, Carvalho Fa. Comparative effects of α2δ-1 ligands in mouse models of colonic hypersensitivity. World J Gastroenterol 2016; 22(31): 7111-7123 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i31/7111.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i31.7111 |
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