Publication Name	World Journal of Hepatology
Manuscript ID	26680
Country	Taiwan

Received	2016-04-21 15:38
Peer-Review Started	2016-04-22 17:24
To Make the First Decision	2016-06-06 17:24
Return for Revision	2016-06-07 19:15
Revised	2016-06-27 17:00
Second Decision	2016-07-11 12:00
Accepted by Journal Editor-in-Chief	2016-07-12 17:51
Accepted by Executive Editor-in-Chief	2016-07-22 11:14
Articles in Press	2016-07-22 11:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-09-06 16:23
Publish the Manuscript Online	2016-09-14 11:02

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Minireviews
Article Title	Inhibition of apoptosis by oncogenic hepatitis B virus X protein: implications for the treatment of hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Chuck C K Chao
Funding Agency and Grant Number
Corresponding Author	Chuck C K Chao, PhD, Department of Biochemistry and Molecular Biology, College of Medicine, Chang Gung University, No.259, Wenhua 1st Rd., Guishan Dist, Taoyuan 33302, Taiwan. cckchao@mail.cgu.edu.tw
Key Words	Hepatitis B virus X protein; Hepatocellular carcinoma; Hepatitis B virus; Hepatoma upregulated protein; p53; Gankyrin; SATB1
Core Tip	Hepatitis B virus X protein (HBx) plays a critical role in the development of hepatocellular carcinoma (HCC). Hepatoma upregulated protein (HURP) is an oncogene that is upregulated in a majority of HCC cases. However, the role of these proteins in the response of HCC cells to chemotherapeutic drugs remains unclear. We show here that the HBx/SATB1/HURP axis plays a critical role in down-regulating p53 and upregulating anti-apoptotic proteins in vitro and in vivo. We discuss the regulation of this novel pathway and its implications in resistance of HCC cells to chemotherapy.
Publish Date	2016-09-14 11:02
Citation	Chao ccK. Inhibition of apoptosis by oncogenic hepatitis B virus X protein: implications for the treatment of hepatocellular carcinoma. World J Hepatol 2016; 8(25): 1061-1066
URL	http://www.wjgnet.com/1948-5182/full/v8/i25/1061.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i25.1061

Full Article (PDF)	WJH-8-1061.pdf
Full Article (Word)	WJH-8-1061.doc
Manuscript File	26680-Review.docx
Answering Reviewers	26680-Answering reviewers.pdf
Audio Core Tip	26680-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	26680-Conflict-of-interest statement.pdf
Copyright License Agreement	26680-Copyright assignment.pdf
Peer-review Report	26680-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	26680-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	26680-Scientific misconduct check.pdf
Scientific Editor Work List	26680-Scientific editor work list.pdf