Publication Name	World Journal of Cardiology
Manuscript ID	2672
Country	India

Received	2013-03-06 19:45
Peer-Review Started	2013-03-07 14:33
To Make the First Decision	2013-04-16 09:07
Return for Revision	2013-04-20 15:25
Revised	2013-04-29 15:53
Second Decision	2013-07-18 15:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-07-19 03:46
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-08-22 10:25
Publish the Manuscript Online	2013-09-05 13:03

ISSN	1949-8462 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Autobiography
Article Title	Blood cellular mutant LXR-α protein stability governs initiation of coronary heart disease
Manuscript Source	Invited Manuscript
All Author List	Mansi Arora, Deepak Kaul and Yash Paul Sharma
Funding Agency and Grant Number	Funding Agency Grant Number Indian Council of Medical Research, New Delhi, India
Corresponding Author	Deepak Kaul, PhD, Professor and Head, Departments of Experimental Medicine, Biotechnology and Cardiology, Post Graduate Institute of Medical Education and Research, Pin-133001, Chandigarh 160012, India. dkaul-24@hotmail.com
Key Words	Mutant liver X receptor-α; Ubiquitination; Breast and ovarian cancer susceptibility 1-associated RING domain 1/breast and ovarian cancer susceptibility 1; Mononuclear Cells; Coronary heart disease subjects; Vitamin D3
Core Tip	The present study proposes that the stability of mutant liver X receptor-α (LXR-α) protein in blood mononuclear cells of human coronary heart disease (CHD) subjects is governed by its ubiquitination dependent degradation by [breast and ovarian cancer susceptibility 1 (BRCA1)-associated RING domain1 (BARD1)]/BRCA1 E3 ubiquitin ligase complex. Additionally, BARD1/BRCA1 expression shows an increasing trend with respect to severity of coronary occlusion. This degradation is rescued to some extent by the ability of Vitamin D3 to bind mutant LXR-α protein thus providing warranted evidence that dietary supplementation of Vitamin D3 in such subjects may be exploited therapeutically.
Publish Date	2013-09-05 13:03
Citation	Arora M, Kaul D, Sharma YP. Blood cellular mutant LXR-α protein stability governs initiation of coronary heart disease. World J Cardiol 2013; 5(8): 305-312
URL	http://www.wjgnet.com/1949-8462/full/v5/i8/305.htm
DOI	http://dx.doi.org/10.4330/wjc.v5.i8.305

Full Article (PDF)	WJC-5-305.pdf
Manuscript File	2672-Review.docx
Answering Reviewers	2672-Answering reviewers.pdf
Copyright License Agreement	2672-Copyright assignment.doc
Peer-review Report	2672-Peer review(s).pdf
Scientific Editor Work List	2672-Scientific editor work list.doc