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10/8/2016 4:54:00 PM | Browse: 853 | Download: 1041
Publication Name World Journal of Clinical Oncology
Manuscript ID 26745
Country/Territory United States
Received
2016-04-25 09:24
Peer-Review Started
2016-04-26 14:05
To Make the First Decision
2016-06-12 09:14
Return for Revision
2016-06-16 10:41
Revised
2016-07-14 06:41
Second Decision
2016-07-20 16:25
Accepted by Journal Editor-in-Chief
2016-07-20 16:44
Accepted by Company Editor-in-Chief
2016-08-08 14:29
Articles in Press
2016-08-08 14:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-09-28 13:16
Publish the Manuscript Online
2016-10-08 16:54
ISSN 2218-4333 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Review
Article Title Oncogenic fingerprint of epidermal growth factor receptor pathway and emerging epidermal growth factor receptor blockade resistance in colorectal cancer
Manuscript Source Invited Manuscript
All Author List Zain A Sobani, Ashwin Sawant, Mikram Jafri, Amit Keith Correa and Ibrahim Halil Sahin
Funding Agency and Grant Number
Corresponding Author Ibrahim Halil Sahin, MD, Department of Medicine, Icahn School of Medicine at Mount Sinai St Luke’s Roosevelt Hospital Center, 1000 10th Avenue, New York, NY 10019, United States. md.ibrahim.halil.sahin@gmail.com
Key Words Epidermal growth factor receptor; Oncogenic signature; Kirsten RAS; BRAF; Cetuximab; Panitumumab; Epidermal growth factor receptor blockade resistance
Core Tip Epidermal growth factor receptor (EGFR) blockade treatment is a well-established targeted therapy in metastatic colorectal cancer (CRC) patients. However, a limited number of patients benefit from EGFR inhibition, with limited time duration of response. This review article discusses the most recent updates from the current-state-of-the-science related to molecular pathways of EGFR signaling, the mechanism of action and efficacy of EGFR blockade treatment, and possible molecular pathways related to EGFR blockade resistance in CRC. We further discuss potential mechanisms contributing to targeted EGFR inhibition. Lastly, future perspectives are discussed to shed some light on efforts to overcome this potential challenge in the era of targeted treatment.
Publish Date 2016-10-08 16:54
Citation Sobani ZA, Sawant A, Jafri M, Correa AK, Sahin IH. Oncogenic fingerprint of epidermal growth factor receptor pathway and emerging epidermal growth factor receptor blockade resistance in colorectal cancer. World J Clin Oncol 2016; 7(5): 340-351
URL http://www.wjgnet.com/2218-4333/full/v7/i5/340.htm
DOI http://dx.doi.org/10.5306/wjco.v7.i5.340
Full Article (PDF) WJCO-7-340.pdf
Full Article (Word) WJCO-7-340.doc
Manuscript File 26745-Review.docx
Answering Reviewers 26745-Answering reviewers.pdf
Audio Core Tip 26745-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 26745-Conflict-of-interest statement.pdf
Copyright License Agreement 26745-Copyright assignment.pdf
Peer-review Report 26745-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 26745-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 26745-Scientific misconduct check.pdf
Scientific Editor Work List 26745-Scientific editor work list.pdf