Publication Name	World Journal of Clinical Oncology
Manuscript ID	26745
Country	United States

Received	2016-04-25 09:24
Peer-Review Started	2016-04-26 14:05
To Make the First Decision	2016-06-12 09:14
Return for Revision	2016-06-16 10:41
Revised	2016-07-14 06:41
Second Decision	2016-07-20 16:25
Accepted by Journal Editor-in-Chief	2016-07-20 16:44
Accepted by Executive Editor-in-Chief	2016-08-08 14:29
Articles in Press	2016-08-08 14:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-09-28 13:16
Publish the Manuscript Online	2016-10-08 16:54

ISSN	2218-4333 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Review
Article Title	Oncogenic fingerprint of epidermal growth factor receptor pathway and emerging epidermal growth factor receptor blockade resistance in colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Zain A Sobani, Ashwin Sawant, Mikram Jafri, Amit Keith Correa and Ibrahim Halil Sahin
Funding Agency and Grant Number
Corresponding Author	Ibrahim Halil Sahin, MD, Department of Medicine, Icahn School of Medicine at Mount Sinai St Luke’s Roosevelt Hospital Center, 1000 10th Avenue, New York, NY 10019, United States. md.ibrahim.halil.sahin@gmail.com
Key Words	Epidermal growth factor receptor; Oncogenic signature; Kirsten RAS; BRAF; Cetuximab; Panitumumab; Epidermal growth factor receptor blockade resistance
Core Tip	Epidermal growth factor receptor (EGFR) blockade treatment is a well-established targeted therapy in metastatic colorectal cancer (CRC) patients. However, a limited number of patients benefit from EGFR inhibition, with limited time duration of response. This review article discusses the most recent updates from the current-state-of-the-science related to molecular pathways of EGFR signaling, the mechanism of action and efficacy of EGFR blockade treatment, and possible molecular pathways related to EGFR blockade resistance in CRC. We further discuss potential mechanisms contributing to targeted EGFR inhibition. Lastly, future perspectives are discussed to shed some light on efforts to overcome this potential challenge in the era of targeted treatment.
Publish Date	2016-10-08 16:54
Citation	Sobani ZA, Sawant A, Jafri M, Correa AK, Sahin IH. Oncogenic fingerprint of epidermal growth factor receptor pathway and emerging epidermal growth factor receptor blockade resistance in colorectal cancer. World J Clin Oncol 2016; 7(5): 340-351
URL	http://www.wjgnet.com/2218-4333/full/v7/i5/340.htm
DOI	http://dx.doi.org/10.5306/wjco.v7.i5.340

Full Article (PDF)	WJCO-7-340.pdf
Full Article (Word)	WJCO-7-340.doc
Manuscript File	26745-Review.docx
Answering Reviewers	26745-Answering reviewers.pdf
Audio Core Tip	26745-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	26745-Conflict-of-interest statement.pdf
Copyright License Agreement	26745-Copyright assignment.pdf
Peer-review Report	26745-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	26745-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	26745-Scientific misconduct check.pdf
Scientific Editor Work List	26745-Scientific editor work list.pdf