Publication Name	World Journal of Gastroenterology
Manuscript ID	26758
Country	Japan

Received	2016-04-26 10:32
Peer-Review Started	2016-04-27 08:30
To Make the First Decision	2016-06-20 14:03
Return for Revision	2016-06-20 16:19
Revised	2016-06-30 19:51
Second Decision	2016-07-25 08:07
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-08-05 17:48
Articles in Press	2016-08-05 17:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-09-29 08:45
Publish the Manuscript Online	2016-10-12 14:18

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Minireviews
Article Title	Circulating tumor DNA as a liquid biopsy target for detection of pancreatic cancer
Manuscript Source	Invited Manuscript
All Author List	Erina Takai and Shinichi Yachida
Funding Agency and Grant Number
Corresponding Author	Erina Takai, PhD, Division of Cancer Genomics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. ertakai@ncc.go.jp
Key Words	Circulating tumor DNA; Pancreatic cancer; Biomarker; Precision medicine; Liquid biopsy
Core Tip	There is a need for minimally-invasive diagnostic tools for detecting pancreatic cancer at an early stage and also novel therapeutic approaches including precision medicine may be feasible. The “liquid biopsy” addresses these unmet clinical needs based on the concept that simple peripheral blood sampling and detection of circulating tumor DNA (ctDNA) could provide diagnostic information. In this topic, we provide an overview of the current status of blood-based tests for diagnosis of pancreatic cancer and the potential utility of ctDNA for precision medicine. We also discuss challenges that remain to be addressed in developing practical ctDNA-based liquid biopsy.
Publish Date	2016-10-12 14:18
Citation	Takai E, Yachida S. Circulating tumor DNA as a liquid biopsy target for detection of pancreatic cancer. World J Gastroenterol 2016; 22(38): 8480-8488
URL	http://www.wjgnet.com/1007-9327/full/v22/i38/8480.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i38.8480

Full Article (PDF)	WJG-22-8480.pdf
Full Article (Word)	WJG-22-8480.doc
Manuscript File	26758-Review.docx
Answering Reviewers	26758-Answering reviewers.pdf
Audio Core Tip	26758-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	26758-Conflict-of-interest statement.pdf
Copyright License Agreement	26758-Copyright assignment.pdf
Peer-review Report	26758-Peer-review(s).pdf
Scientific Misconduct Check	26758-Scientific misconduct check.pdf
Scientific Editor Work List	26758-Scientific editor work list.pdf