Publication Name	World Journal of Gastroenterology
Manuscript ID	26797
Country	Belgium

Received	2016-04-27 11:01
Peer-Review Started	2016-04-28 08:40
To Make the First Decision	2016-06-20 14:04
Return for Revision	2016-06-20 16:49
Revised	2016-06-28 19:12
Second Decision	2016-07-21 18:37
Accepted by Journal Editor-in-Chief	2016-07-21 19:19
Accepted by Executive Editor-in-Chief	2016-08-01 15:55
Articles in Press	2016-08-01 15:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-08-30 10:33
Publish the Manuscript Online	2016-09-08 10:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category
Manuscript Type	Review
Article Title	Pathophysiology of colorectal peritoneal carcinomatosis: Role of the peritoneum
Manuscript Source	Unsolicited Manuscript
All Author List	Lieselotte Lemoine, Paul Sugarbaker and Kurt Van der Speeten
Funding Agency and Grant Number	Funding Agency Grant Number Agency for Innovation by Science and Technology (IWT) in Brussels, Belgium to Lemoine L Foundation Limburg Sterk Merk (LSM), Hasselt University, Ziekenhuis Oost-Limburg and Jessa Hospital, Belgium to Lemoine L
Corresponding Author	Kurt Van der Speeten, MD, PhD, Department of Surgical Oncology, Ziekenhuis Oost-Limburg, Schiepse Bos 6, Genk, Limburg, 3600, Belgium. kurt.vanderspeeten@zol.be
Key Words	Peritoneal carcinomatosis; Pathophysiology; Peritoneal metastatic cascade; Cytoreductive surgery; Peritoneum; Hyperthermic intraperitoneal peroperative chemotherapy
Core Tip	Colorectal peritoneal carcinomatosis (PC) is associated with poor prognosis and bad quality of life for patients in their terminal stages of disease. A loco-regional treatment, combining cytoreductive surgery and hyperthermic intraperitoneal peroperative chemotherapy, is associated with significant mor?bidity and mortality. Therefore, a comprehensive understanding of the molecular events involved in peritoneal disease spread and subsequent careful patient selection is paramount to avoid unnecessary toxicity. This manuscript highlights current data regarding the molecular mechanisms underlying the development of colorectal PC with a special focus on the peritoneum and the role of the surgeon in peritoneal disease spread.
Publish Date	2016-09-08 10:53
Citation	Lemoine L, Sugarbaker P, Van der Speeten K. Pathophysiology of colorectal peritoneal carcinomatosis: Role of the peritoneum. World J Gastroenterol 2016; 22(34): 7692-7707
URL	http://www.wjgnet.com/1007-9327/full/v22/i34/7692.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i34.7692

Full Article (PDF)	WJG-22-7692.pdf
Full Article (Word)	WJG-22-7692.doc
Manuscript File	26797-Review.docx
Answering Reviewers	26797-Answering reviewers.pdf
Audio Core Tip	26797-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	26797-Conflict-of-interest statement.pdf
Copyright License Agreement	26797-Copyright assignment.pdf
Peer-review Report	26797-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	26797-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	26797-Scientific misconduct check.pdf
Scientific Editor Work List	26797-Scientific editor work list.pdf