| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
|
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Hypolactasia is associated with insulin resistance in nonalcoholic steatohepatitis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Daniel Ferraz de Campos Mazo, Rejane Mattar, José Tadeu Stefano, Joyce Matie Kinoshita da Silva-Etto, Márcio Augusto Diniz, Sebastião Mauro Bezerra Duarte, Fabíola Rabelo, Rodrigo Vieira Costa Lima, Priscila Brizolla de Campos, Flair José Carrilho and Claudia P Oliveira |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Claudia P Oliveira, MD, PhD, Division of Gastroenterology and Hepatology, Department of Gastroenterology (LIM 07), University of São Paulo School of Medicine, Av Dr Eneas de Carvalho Aguiar 255, 9° Andar, Sala 9159, São Paulo 05403-000, Brazil. cpm@.usp.br |
| Key Words |
Lactose intolerance; Genetic polymorphism; Insulin resistance; Non-alcoholic fatty liver disease; Nonalcoholic steatohepatitis |
| Core Tip |
Non-alcoholic fatty liver disease (NAFLD) exhibits a close relationship with metabolic syndrome (MetS), but the associations of the lactase non-per-sistence/lactase persistence genotypes with MetS components are controversial. Therefore, we assessed hypolactasia (LCT-13910CC) and lactase persistence genotypes in 102 Brazilian NAFLD patients in comparison with 501 healthy controls, the associations of these polymorphisms were verified with the results of bio-chemical tests, MetS and severity of liver histology in nonalcoholic steatohepatitis (NASH) patients. No differences in the LCT-13910C>T polymorphisms were noted between the NAFLD and controls, but hypolactasia increased the risk of insulin resistance in the NASH patients. |
| Publish Date |
2016-08-25 10:46 |
| Citation |
de Campos Mazo DF, Mattar R, Stefano JT, da Silva-Etto JMK, Diniz MA, Duarte SMB, Rabelo F, Lima RVC, de Campos PB, Carrilho FJ, Oliveira CP. Hypolactasia is associated with insulin resistance in nonalcoholic steatohepatitis. World J Hepatol 2016; 8(24): 1019-1027 |
| URL |
http://www.wjgnet.com/1948-5182/full/v8/i24/1019.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v8.i24.1019 |
