Publication Name	World Journal of Hepatology
Manuscript ID	26802
Country	Brazil

Received	2016-04-27 10:31
Peer-Review Started	2016-04-28 10:06
First Decision by Editorial Office Director
Return for Revision	2016-05-17 18:33
Revised	2016-06-08 07:40
Publication Fee Transferred
Second Decision by Editor	2016-07-05 17:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2016-07-18 10:47
Articles in Press	2016-07-18 10:47
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-08-08 17:31
Publish the Manuscript Online	2016-08-25 10:46

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Hypolactasia is associated with insulin resistance in nonalcoholic steatohepatitis
Manuscript Source	Invited Manuscript
All Author List	Daniel Ferraz de Campos Mazo, Rejane Mattar, José Tadeu Stefano, Joyce Matie Kinoshita da Silva-Etto, Márcio Augusto Diniz, Sebastião Mauro Bezerra Duarte, Fabíola Rabelo, Rodrigo Vieira Costa Lima, Priscila Brizolla de Campos, Flair José Carrilho and Claudia P Oliveira
Funding Agency and Grant Number
Corresponding Author	Claudia P Oliveira, MD, PhD, Division of Gastroenterology and Hepatology, Department of Gastroenterology (LIM 07), University of São Paulo School of Medicine, Av Dr Eneas de Carvalho Aguiar 255, 9° Andar, Sala 9159, São Paulo 05403-000, Brazil. cpm@.usp.br
Key Words	Lactose intolerance; Genetic polymorphism; Insulin resistance; Non-alcoholic fatty liver disease; Nonalcoholic steatohepatitis
Core Tip	Non-alcoholic fatty liver disease (NAFLD) exhibits a close relationship with metabolic syndrome (MetS), but the associations of the lactase non-per-sistence/lactase persistence genotypes with MetS components are controversial. Therefore, we assessed hypolactasia (LCT-13910CC) and lactase persistence genotypes in 102 Brazilian NAFLD patients in comparison with 501 healthy controls, the associations of these polymorphisms were verified with the results of bio-chemical tests, MetS and severity of liver histology in nonalcoholic steatohepatitis (NASH) patients. No differences in the LCT-13910C>T polymorphisms were noted between the NAFLD and controls, but hypolactasia increased the risk of insulin resistance in the NASH patients.
Publish Date	2016-08-25 10:46
Citation	de Campos Mazo DF, Mattar R, Stefano JT, da Silva-Etto JMK, Diniz MA, Duarte SMB, Rabelo F, Lima RVC, de Campos PB, Carrilho FJ, Oliveira CP. Hypolactasia is associated with insulin resistance in nonalcoholic steatohepatitis. World J Hepatol 2016; 8(24): 1019-1027
URL	http://www.wjgnet.com/1948-5182/full/v8/i24/1019.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i24.1019

Full Article (PDF)	WJH-8-1019.pdf
Full Article (Word)	WJH-8-1019.doc
Manuscript File	26802-Review.doc
Answering Reviewers	26802-Answering reviewers.pdf
Audio Core Tip	26802-Audio core tip.aif
Biostatistics Review Certificate	26802-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	26802-Conflict-of-interest statement.pdf
Copyright License Agreement	26802-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20160426214711.docx
Institutional Review Board Approval Form or Document	26802-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	26802-Language certificate.pdf
Supplementary Material	Supplementary_Material_20160426214736.doc
Peer-review Report	26802-Peer-review(s).pdf
Scientific Misconduct Check	26802-Scientific misconduct check.pdf
Scientific Editor Work List	26802-Scientific editor work list.pdf