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8/25/2016 10:46:00 AM | Browse: 487 | Download: 537
Publication Name World Journal of Hepatology
Manuscript ID 26802
Country/Territory Brazil
Received
2016-04-27 10:31
Peer-Review Started
2016-04-28 10:06
To Make the First Decision
2016-05-16 11:04
Return for Revision
2016-05-17 18:33
Revised
2016-06-08 07:40
Second Decision
2016-07-05 17:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-07-18 10:47
Articles in Press
2016-07-18 10:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-08-08 17:31
Publish the Manuscript Online
2016-08-25 10:46
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Observational Study
Article Title Hypolactasia is associated with insulin resistance in nonalcoholic steatohepatitis
Manuscript Source Invited Manuscript
All Author List Daniel Ferraz de Campos Mazo, Rejane Mattar, José Tadeu Stefano, Joyce Matie Kinoshita da Silva-Etto, Márcio Augusto Diniz, Sebastião Mauro Bezerra Duarte, Fabíola Rabelo, Rodrigo Vieira Costa Lima, Priscila Brizolla de Campos, Flair José Carrilho and Claudia P Oliveira
Funding Agency and Grant Number
Corresponding author Claudia P Oliveira, MD, PhD, Division of Gastroenterology and Hepatology, Department of Gastroenterology (LIM 07), University of São Paulo School of Medicine, Av Dr Eneas de Carvalho Aguiar 255, 9° Andar, Sala 9159, São Paulo 05403-000, Brazil. cpm@.usp.br
Keywords Lactose intolerance; Genetic polymorphism; Insulin resistance; Non-alcoholic fatty liver disease; Nonalcoholic steatohepatitis
Core Tip Non-alcoholic fatty liver disease (NAFLD) exhibits a close relationship with metabolic syndrome (MetS), but the associations of the lactase non-per-sistence/lactase persistence genotypes with MetS components are controversial. Therefore, we assessed hypolactasia (LCT-13910CC) and lactase persistence genotypes in 102 Brazilian NAFLD patients in comparison with 501 healthy controls, the associations of these polymorphisms were verified with the results of bio-chemical tests, MetS and severity of liver histology in nonalcoholic steatohepatitis (NASH) patients. No differences in the LCT-13910C>T polymorphisms were noted between the NAFLD and controls, but hypolactasia increased the risk of insulin resistance in the NASH patients.
Publish Date 2016-08-25 10:46
Citation de Campos Mazo DF, Mattar R, Stefano JT, da Silva-Etto JMK, Diniz MA, Duarte SMB, Rabelo F, Lima RVC, de Campos PB, Carrilho FJ, Oliveira CP. Hypolactasia is associated with insulin resistance in nonalcoholic steatohepatitis. World J Hepatol 2016; 8(24): 1019-1027
Url http://www.wjgnet.com/1948-5182/full/v8/i24/1019.htm
DOI http://dx.doi.org/10.4254/wjh.v8.i24.1019
Full Article (PDF) WJH-8-1019.pdf
Full Article (Word) WJH-8-1019.doc
Manuscript File 26802-Review.doc
Answering Reviewers 26802-Answering reviewers.pdf
Audio Core Tip 26802-Audio core tip.aif
Biostatistics Review Certificate 26802-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 26802-Conflict-of-interest statement.pdf
Copyright License Agreement 26802-Copyright assignment.pdf
Data Sharing Statement 26802-Data sharing statement.pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20160426214711.docx
Institutional Review Board Approval Form or Document 26802-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 26802-Language certificate.pdf
Supplementary Material Supplementary_Material_20160426214736.doc
Peer-review Report 26802-Peer-review(s).pdf
Scientific Misconduct Check 26802-Scientific misconduct check.pdf
Scientific Editor Work List 26802-Scientific editor work list.pdf