Publication Name	World Journal of Stem Cells
Manuscript ID	26827
Country	France

Received	2016-04-28 15:55
Peer-Review Started	2016-04-28 22:45
To Make the First Decision	2016-06-12 09:25
Return for Revision	2016-06-16 11:39
Revised	2016-06-18 07:07
Second Decision	2016-06-27 16:51
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-07-13 13:43
Articles in Press	2016-07-13 13:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-08-12 10:42
Publish the Manuscript Online	2016-08-19 16:02

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Minireviews
Article Title	Targeting stem cells by radiation: From the biological angle to clinical aspects
Manuscript Source	Invited Manuscript
All Author List	Alexis Vallard, Sophie Espenel, Jean-Baptiste Guy, Peng Diao, Yaoxiong Xia, Anis El Meddeb Hamrouni, Majed Ben Mrad, Alexander Tuan Falk, Claire Rodriguez-Lafrasse, Chloé Rancoule and Nicolas Magné
Funding Agency and Grant Number
Corresponding Author	Nicolas Magné, MD, PhD, Department of Radiotherapy, Lucien Neuwirth Cancer Institute, 108 bis, Avenue Albert Raimond, BP 60008, 42271 Saint-Priest en Jarez, France. nicolas.magne@icloire.fr
Key Words	Cancer; Neoplastic stem cells; Radiation therapy; Efficacy; Toxicity
Core Tip	Radiotherapy is a cornerstone of anticancer treatments. However, significant levels of toxicity and recurrences are still reported. On the one hand, cancer stem cells have been recently suggested to be the root of radio-resistance, with strong pre-clinical rational. One the other hand, convincing pre-clinical data suggesting the importance of healthy tissue stem cells radiation-induced destruction in long term side effects of radiotherapy surfaced. This article provides an overview of the available literature analyzing from the clinical efficacy and toxicity perspective the interactions between stem cells and radiation. Significant improve-ment of radiotherapy toxicity/efficacy ratio is suggested.
Publish Date	2016-08-19 16:02
Citation	Vallard A, Espenel S, Guy JB, Diao P, Xia Y, El Meddeb Hamrouni A, Ben Mrad M, Falk AT, Rodriguez-Lafrasse C, Rancoule C, Magné N. Targeting stem cells by radiation: From the biological angle to clinical aspects. World J Stem Cells 2016; 8(8): 243-250
URL	http://www.wjgnet.com/1948-0210/full/v8/i8/243.htm
DOI	http://dx.doi.org/10.4252/wjsc.v8.i8.243

Full Article (PDF)	WJSC-8-243.pdf
Full Article (Word)	WJSC-8-243.doc
Manuscript File	26827-Review.doc
Answering Reviewers	26827-Answering reviewers.pdf
Audio Core Tip	26827-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	26827-Conflict-of-interest statement.pdf
Copyright License Agreement	26827-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	26827-Language certificate.pdf
Peer-review Report	26827-Peer-review(s).pdf
Scientific Misconduct Check	26827-Scientific misconduct check.pdf
Scientific Editor Work List	26827-Scientific editor work list.pdf