Publication Name	World Journal of Gastroenterology
Manuscript ID	26834
Country	Italy

Received	2016-04-28 16:05
Peer-Review Started	2016-04-29 09:04
To Make the First Decision	2016-07-13 13:30
Return for Revision	2016-07-18 08:41
Revised	2016-08-01 16:02
Second Decision	2016-08-05 08:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-08-10 15:49
Articles in Press	2016-08-10 15:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-08-29 14:06
Publish the Manuscript Online	2016-09-14 19:04

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Pathology
Manuscript Type	Review
Article Title	HER2 aberrations and heterogeneity in cancers of the digestive system: Implications for pathologists and gastroenterologists
Manuscript Source	Invited Manuscript
All Author List	Nicola Fusco and Silvano Bosari
Funding Agency and Grant Number
Corresponding Author	Silvano Bosari, MD, Professor, Division of Pathology, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Via Francesco Sforza, 35, 20122 Milan, Italy. silvano.bosari@unimi.it
Key Words	HER2; Digestive system; Gastrointestinal tract; Gastric cancer; Colon cancer; Esophageal cancer; Gastroesophageal junction cancer; Biliary tract cancer; Gallbladder cancer; Liver cancer; Pancreas cancer
Core Tip	Numerous studies have broadened our under-standing of HER2 as a critical oncogene in many human cancers, including tumors of the digestive system. Due to the increasing importance of HER2 testing in this heterogeneous group of tumors, in this review we seek to outline the current state of knowledge of HER2 alterations in the most common malignancies occurring in the digestive system, to examine the operational impli-cations of HER2 testing as a biomarker and potentially targetable gene, and discuss immediate future perspec-tives for pathologists and gastroenterologists.
Publish Date	2016-09-14 19:04
Citation	Fusco N, Bosari S. HER2 aberrations and heterogeneity in cancers of the digestive system: Implications for pathologists and gastroenterologists. World J Gastroenterol 2016; 22(35): 7926-7937
URL	http://www.wjgnet.com/1007-9327/full/v22/i35/7926.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i35.7926

Full Article (PDF)	WJG-22-7926.pdf
Full Article (Word)	WJG-22-7926.doc
Manuscript File	26834-Review.docx
Answering Reviewers	26834-Answering reviewers.pdf
Audio Core Tip	26834-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	26834-Conflict-of-interest statement.pdf
Copyright License Agreement	26834-Copyright assignment.pdf
Peer-review Report	26834-Peer-review(s).pdf
Scientific Misconduct Check	26834-Scientific misconduct check.pdf
Scientific Editor Work List	26834-Scientific editor work list.pdf