Publication Name	World Journal of Stem Cells
Manuscript ID	26866
Country	China

Received	2016-04-29 14:32
Peer-Review Started	2016-04-29 18:25
To Make the First Decision	2016-06-12 09:29
Return for Revision	2016-06-16 12:17
Revised	2016-07-09 15:58
Second Decision	2016-07-20 16:27
Accepted by Journal Editor-in-Chief	2016-07-21 14:25
Accepted by Executive Editor-in-Chief	2016-08-01 15:34
Articles in Press	2016-08-01 15:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-09-13 13:17
Publish the Manuscript Online	2016-09-19 15:28

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Immunology
Manuscript Type	Frontier
Article Title	Immunomodulation by mesenchymal stem cells: Interplay between mesenchymal stem cells and regulatory lymphocytes
Manuscript Source	Invited Manuscript
All Author List	Oscar Ka-Fai Ma and Koon Ho Chan
Funding Agency and Grant Number	Funding Agency Grant Number Research Fund for Central Nervous System Inflammation Demyelinating Disorders (CNSIDD) 200006333
Corresponding Author	Dr. Koon Ho Chan, Department of Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, 4/F Professorial Block, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China. koonho@hkucc.hku.hk
Key Words	Mesenchymal stem cells; Regulatory T cells; Regulatory B cells; Immunomodulation; Autoimmunity
Core Tip	In this review, we summarized the mechanisms involved in regulatory T (Treg) and B (Breg) cell induction by mesenchymal stem cells (MSCs). In an inflammatory environment, MSCs secrete various anti-inflammatory cytokines, actively interact with immune cells and modulate them to acquire regulatory properties, thus, generate a tolerogenic environment. Particularly, by inducing Treg and Breg cells, the immunomodulation of MSCs is amplified. Therefore, genetic engineered MSCs to enhance their ability to induce Treg and Breg cells may increase their therapeutic efficacy.
Publish Date	2016-09-19 15:28
Citation	Ma OKF, Chan KH. Immunomodulation by mesenchymal stem cells: Interplay between mesenchymal stem cells and regulatory lymphocytes. World J Stem Cells 2016; 8(9): 268-278
URL	http://www.wjgnet.com/1948-0210/full/v8/i9/268.htm
DOI	http://dx.doi.org/10.4252/wjsc.v8.i9.268

Full Article (PDF)	WJSC-8-268.pdf
Full Article (Word)	WJSC-8-268.doc
Manuscript File	26866-Review.docx
Answering Reviewers	26866-Answering reviewers.pdf
Audio Core Tip	26866-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	26866-Conflict-of-interest statement.pdf
Copyright License Agreement	26866-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	26866-Grant application form(s).PDF
Peer-review Report	26866-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	26866-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	26866-Scientific misconduct check.pdf
Scientific Editor Work List	26866-Scientific editor work list.pdf