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Publication Name World Journal of Hepatology
Manuscript ID 26954
Country of Manuscript Source Australia
2016-05-02 18:03
Peer-Review Started
2016-05-03 14:15
To Make the First Decision
2016-06-12 09:38
Return for Revision
2016-06-17 16:44
2016-07-13 06:15
Second Decision
2016-08-08 15:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-08-18 11:54
Articles in Press
2016-08-18 11:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-09-18 11:53
Publish the Manuscript Online
2016-09-22 09:52
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Clinical Trials Study
Article Title Independent effects of diet and exercise training on fat oxidation in non-alcoholic fatty liver disease
Manuscript Source Invited Manuscript
All Author List Ilaria Croci, Nuala M Byrne, Veronique S Chachay, Andrew P Hills, Andrew D Clouston, Trisha M O’Moore-Sullivan, Johannes B Prins, Graeme A Macdonald and Ingrid J Hickman
Funding Agency and Grant Number
Funding Agency Grant Number
National Health and Medical Research Council of Australia
Lions Medical Research Foundation
Corresponding author Ilaria Croci, PhD, School of Human Movement and Nutrition Sciences, University of Queensland, Blair Drive, St. Lucia 4072, Australia. ilaria.croci@uqconnect.edu.au
Keywords Non-alcoholic steatohepatitis; Steatosis; Fat and carbohydrate oxidation; Exercise; Fitness; Beta-hydroxybutyrate; Ketone bodies; Fatty acid oxidation
Core Tip We investigated hepatic fat oxidation and whole-body substrate oxidation under basal, insulin-stimulated and exercise conditions before and after 6 mo of circuit exercise training (EX) or dietary energy restriction (ER) in patients with non-alcoholic fatty liver disease. ER increased β-hydroxybutyrate concentrations (a marker of hepatic fat oxidation) and reduced severity of steatosis, but did not change substrate oxidation rates during acute exercise. EX improved substrate oxidation under basal, insulin-stimulated and exercise conditions, but not β-hydroxybutyrate concentrations and severity of disease. Increase in β-hydroxybutyrate was associated with decrease in hepatic steatosis and this could be one mechanism through which the ER group achieved reduc-tion in steatosis.
Publish Date 2016-09-22 09:52
Citation Croci I, Byrne NM, Chachay VS, Hills AP, Clouston AD, O’Moore-Sullivan TM, Prins JB, Macdonald GA, Hickman IJ. Independent effects of diet and exercise training on fat oxidation in non-alcoholic fatty liver disease. World J Hepatol 2016; 8(27): 1137-1148
Url http://www.wjgnet.com/1948-5182/full/v8/i27/1137.htm
DOI http://dx.doi.org/10.4254/wjh.v8.i27.1137
Full Article (PDF) WJH-8-1137.pdf
Full Article (Word) WJH-8-1137.doc
Manuscript File 26954-Review.docx
Answering Reviewers 26954-Answering reviewers.pdf
Audio Core Tip 26954-Audio core tip
Biostatistics Review Certificate 26954-Biostatistics statement.pdf
Clinical Trial Registration Statement 26954-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form 26954-Conflict-of-interest statement.pdf
Copyright License Agreement 26954-Copyright assignment.pdf
Data Sharing Statement 26954-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 26954-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 26954-Clinical trial registration statement.pdf
Institutional Review Board Approval Form or Document 26954-Institutional review board statement.pdf
Peer-review Report 26954-Peer-review(s).pdf
Scientific Misconduct Check 26954-Scientific misconduct check.pdf
Scientific Editor Work List 26954-Scientific editor work list.pdf