Publication Name	World Journal of Hepatology
Manuscript ID	26954
Country	Australia

Received	2016-05-02 18:03
Peer-Review Started	2016-05-03 14:15
To Make the First Decision	2016-06-12 09:38
Return for Revision	2016-06-17 16:44
Revised	2016-07-13 06:15
Second Decision	2016-08-08 15:30
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-08-18 11:54
Articles in Press	2016-08-18 11:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-09-18 11:53
Publish the Manuscript Online	2016-09-22 09:52

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Clinical Trials Study
Article Title	Independent effects of diet and exercise training on fat oxidation in non-alcoholic fatty liver disease
Manuscript Source	Invited Manuscript
All Author List	Ilaria Croci, Nuala M Byrne, Veronique S Chachay, Andrew P Hills, Andrew D Clouston, Trisha M O’Moore-Sullivan, Johannes B Prins, Graeme A Macdonald and Ingrid J Hickman
Funding Agency and Grant Number	Funding Agency Grant Number National Health and Medical Research Council of Australia Lions Medical Research Foundation
Corresponding Author	Ilaria Croci, PhD, School of Human Movement and Nutrition Sciences, University of Queensland, Blair Drive, St. Lucia 4072, Australia. ilaria.croci@uqconnect.edu.au
Key Words	Non-alcoholic steatohepatitis; Steatosis; Fat and carbohydrate oxidation; Exercise; Fitness; Beta-hydroxybutyrate; Ketone bodies; Fatty acid oxidation
Core Tip	We investigated hepatic fat oxidation and whole-body substrate oxidation under basal, insulin-stimulated and exercise conditions before and after 6 mo of circuit exercise training (EX) or dietary energy restriction (ER) in patients with non-alcoholic fatty liver disease. ER increased β-hydroxybutyrate concentrations (a marker of hepatic fat oxidation) and reduced severity of steatosis, but did not change substrate oxidation rates during acute exercise. EX improved substrate oxidation under basal, insulin-stimulated and exercise conditions, but not β-hydroxybutyrate concentrations and severity of disease. Increase in β-hydroxybutyrate was associated with decrease in hepatic steatosis and this could be one mechanism through which the ER group achieved reduc-tion in steatosis.
Publish Date	2016-09-22 09:52
Citation	Croci I, Byrne NM, Chachay VS, Hills AP, Clouston AD, O’Moore-Sullivan TM, Prins JB, Macdonald GA, Hickman IJ. Independent effects of diet and exercise training on fat oxidation in non-alcoholic fatty liver disease. World J Hepatol 2016; 8(27): 1137-1148
URL	http://www.wjgnet.com/1948-5182/full/v8/i27/1137.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i27.1137

Full Article (PDF)	WJH-8-1137.pdf
Full Article (Word)	WJH-8-1137.doc
Manuscript File	26954-Review.docx
Answering Reviewers	26954-Answering reviewers.pdf
Audio Core Tip	26954-Audio core tip
Biostatistics Review Certificate	26954-Biostatistics statement.pdf
Clinical Trial Registration Statement	26954-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	26954-Conflict-of-interest statement.pdf
Copyright License Agreement	26954-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	26954-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	26954-Clinical trial registration statement.pdf
Institutional Review Board Approval Form or Document	26954-Institutional review board statement.pdf
Peer-review Report	26954-Peer-review(s).pdf
Scientific Misconduct Check	26954-Scientific misconduct check.pdf
Scientific Editor Work List	26954-Scientific editor work list.pdf