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Articles Published Processes
9/14/2016 7:04:00 PM | Browse: 1108 | Download: 1634
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Received |
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2016-05-03 09:42 |
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Peer-Review Started |
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2016-05-03 12:21 |
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To Make the First Decision |
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2016-06-20 10:51 |
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Return for Revision |
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2016-06-27 16:58 |
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Revised |
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2016-07-12 10:44 |
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Second Decision |
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2016-07-19 12:13 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-08-10 15:46 |
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Articles in Press |
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2016-08-10 15:46 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-08-21 08:56 |
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Typeset the Manuscript |
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2016-09-05 14:40 |
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Publish the Manuscript Online |
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2016-09-14 19:04 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Oncolytic viruses against cancer stem cells: A promising approach for gastrointestinal cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Fang Huang, Bin-Rong Wang, Ye-Qing Wu, Fan-Chao Wang, Jian Zhang and Yi-Gang Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81272687 |
| 521 Talent Project of Zhejiang Sci-Tech University |
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| Natural Science Foundation of Zhejiang Province of China |
LZ13H160004 |
| Natural Science Foundation of Zhejiang Province of China |
LY16H160056 |
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| Corresponding Author |
Yi-Gang Wang, Xinyuan Institute of Medicine and Biotechnology, School of Life Sciences, Zhejiang Sci-Tech University, No. 5, Road 2, Xiasha District, Hangzhou 310018, Zhejiang Province, China. wangyigang43@163.com |
| Key Words |
Cancer stem cells; Gastrointestinal cancer; Oncolytic virotherapy; Molecular mechanism |
| Core Tip |
Cancer stem cells (CSCs) are derived from tumor cells, which are responsible for tumor relapse and drug resistance. The high incidence, lethality, relapse and drug resistance of gastrointestinal cancer requires a novel therapeutic strategy against CSCs. Oncolytic viruses hold much promise because they kill tumor cells but are minimally toxic to normal cells. Isolation and identification of CSC markers for treatment of gastrointestinal cancer will benefit the engineering of oncolytic viruses and targeting anti-tumor effects. This paper reviews research on oncolytic viruses against gastrointestinal CSCs, and toxicity and immunological barriers to oncolytic virotherapy, and proposes alternative strategies.
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| Publish Date |
2016-09-14 19:04 |
| Citation |
Huang F, Wang BR, Wu YQ, Wang FC, Zhang J, Wang YG. Oncolytic viruses against cancer stem cells: A promising approach for gastrointestinal cancer. World J Gastroenterol 2016; 22(35): 7999-8009 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i35/7999.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i35.7999 |
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