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9/14/2016 7:04:00 PM | Browse: 958 | Download: 1335
Publication Name World Journal of Gastroenterology
Manuscript ID 26981
Country/Territory China
Received
2016-05-03 09:42
Peer-Review Started
2016-05-03 12:21
To Make the First Decision
2016-06-20 10:51
Return for Revision
2016-06-27 16:58
Revised
2016-07-12 10:44
Second Decision
2016-07-19 12:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-08-10 15:46
Articles in Press
2016-08-10 15:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
2016-08-21 08:56
Typeset the Manuscript
2016-09-05 14:40
Publish the Manuscript Online
2016-09-14 19:04
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Review
Article Title Oncolytic viruses against cancer stem cells: A promising approach for gastrointestinal cancer
Manuscript Source Invited Manuscript
All Author List Fang Huang, Bin-Rong Wang, Ye-Qing Wu, Fan-Chao Wang, Jian Zhang and Yi-Gang Wang
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81272687
521 Talent Project of Zhejiang Sci-Tech University
Natural Science Foundation of Zhejiang Province of China LZ13H160004
Natural Science Foundation of Zhejiang Province of China LY16H160056
Corresponding Author Yi-Gang Wang, Xinyuan Institute of Medicine and Biotechnology, School of Life Sciences, Zhejiang Sci-Tech University, No. 5, Road 2, Xiasha District, Hangzhou 310018, Zhejiang Province, China. wangyigang43@163.com
Key Words Cancer stem cells; Gastrointestinal cancer; Oncolytic virotherapy; Molecular mechanism
Core Tip Cancer stem cells (CSCs) are derived from tumor cells, which are responsible for tumor relapse and drug resistance. The high incidence, lethality, relapse and drug resistance of gastrointestinal cancer requires a novel therapeutic strategy against CSCs. Oncolytic viruses hold much promise because they kill tumor cells but are minimally toxic to normal cells. Isolation and identification of CSC markers for treatment of gastrointestinal cancer will benefit the engineering of oncolytic viruses and targeting anti-tumor effects. This paper reviews research on oncolytic viruses against gastrointestinal CSCs, and toxicity and immunological barriers to oncolytic virotherapy, and proposes alternative strategies.
Publish Date 2016-09-14 19:04
Citation Huang F, Wang BR, Wu YQ, Wang FC, Zhang J, Wang YG. Oncolytic viruses against cancer stem cells: A promising approach for gastrointestinal cancer. World J Gastroenterol 2016; 22(35): 7999-8009
URL http://www.wjgnet.com/1007-9327/full/v22/i35/7999.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i35.7999
Full Article (PDF) WJG-22-7999.pdf
Full Article (Word) WJG-22-7999.doc
Manuscript File 26981-Review.doc
Answering Reviewers 26981-Answering reviewers.pdf
Audio Core Tip 26981-Audio core tip.MP3
Conflict-of-Interest Disclosure Form 26981-Conflict-of-interest statement.pdf
Copyright License Agreement 26981-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 26981-Grant application form(s).pdf
Peer-review Report 26981-Peer-review(s).pdf
Scientific Misconduct Check 26981-Scientific misconduct check.pdf
Scientific Editor Work List 26981-Scientific editor work list.pdf