Publication Name	World Journal of Gastroenterology
Manuscript ID	2699
Country	China

Received	2013-03-07 17:55
Peer-Review Started
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Return for Revision
Revised	2013-03-07 19:30
Second Decision	2013-03-26 17:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-03-27 13:01
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Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-04-24 15:48
Publish the Manuscript Online	2013-05-02 10:59

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Overexpression of carbonic anhydrase Ⅱ and Ki-67 proteins in prognosis of gastrointestinal stromal tumors
Manuscript Source	Invited Manuscript
All Author List	Li-Cheng Liu, Wen-Tong Xu, Xin Wu, Po Zhao, Ya-Li Lv and Lin Chen
Funding Agency and Grant Number
Corresponding Author	Wen-Tong Xu, MD, Department of General Surgery, General Hospital of PLA, 28 Fuxing Road, Beijing 100853, China. xuwentong@medmail.com.cn
Key Words	Gastrointestinal stromal tumors; Carbonic anhydrase; CD117; Ki-67; Prognostic factor
Core Tip	Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors with a wide spectrum of clinical behavior. This is the first study showing the prognostic significance of carbonic anhydrase Ⅱ (CA Ⅱ) and Ki-67. The 1-, 3- and 5-year survival rates were 90.0%, 82.0% and 72.0%. However, in patients with positive CA Ⅱ or Ki-67, the survival rates were 92.0%, 83.0% and 77.0% or 83.0%, 66.6% and 53.0%, respectively. Our study indicates that CA Ⅱ has strong expression in GISTs and prognosis with high CA Ⅱ expression is better than that with low or no expression, suggesting that CA Ⅱ is both a diagnostic and prognostic biomarker for GIST.
Publish Date	2013-05-02 10:59
Citation	Liu LC, Xu WT, Wu X, Zhao P, Lv YL, Chen L. Overexpression of carbonic anhydrase Ⅱ and Ki-67 proteins in prognosis of gastrointestinal stromal tumors. World J Gastroenterol 2013; 19(16): 2473-2480
URL	http://www.wjgnet.com/1007-9327/full/v19/i16/2473.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i16.2473

Full Article (PDF)	WJG-19-2473.pdf
Manuscript File	2699-Review.doc
Answering Reviewers	2699-Answering reviewers.doc
Copyright License Agreement	2699-Copyright assignment.doc
Non-Native Speakers of English Editing Certificate	2699-Language certificate.doc
Peer-review Report	2699-Peer review(s).pdf
Scientific Editor Work List	2699-Scientific editor work list.doc