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Articles Published Processes
9/26/2016 8:04:00 AM | Browse: 1044 | Download: 2114
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Received |
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2016-05-04 09:26 |
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Peer-Review Started |
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2016-05-04 14:26 |
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To Make the First Decision |
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2016-05-27 11:09 |
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Return for Revision |
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2016-05-27 15:28 |
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Revised |
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2016-06-09 16:35 |
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Second Decision |
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2016-07-07 10:06 |
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Accepted by Journal Editor-in-Chief |
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2016-07-07 13:56 |
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Accepted by Executive Editor-in-Chief |
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2016-07-21 16:02 |
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Articles in Press |
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2016-07-21 16:02 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-09-09 10:51 |
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Publish the Manuscript Online |
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2016-09-26 08:04 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pathology |
| Manuscript Type |
Basic Study |
| Article Title |
Carbonic anhydrase enzymes Ⅱ, Ⅶ, Ⅸ and XII in colorectal carcinomas
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Pia Viikilä, Antti J Kivelä, Harri Mustonen, Selja Koskensalo, Abdul Waheed, William S Sly, Jaromir Pastorek, Silvia Pastorekova, Seppo Parkkila and Caj Haglund |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Sigrid Jusélius Foundation |
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| Medical Research Funds of Tampere University Hospital and Helsinki University Hospital |
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| Jane and Aatos Erkko Foundation |
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| Corresponding Author |
Pia Viikilä, MD, School of Medicine, University of Tampere and Fimlab Ltd, Tampere University Hospital, Medisiinarinkatu 3, 33014 Tampere, Finland. viikila.pia.m@student.uta.fi |
| Key Words |
Biomarker; Carbonic anhydrase; Colorectal cancer; Immunohistochemistry; Prognosis; Survival |
| Core Tip |
Our aim was to investigate expression of four alpha-carbonic anhydrases (CAs) in colorectal carcinomas (CRC) and compare the results with patients’ survival. CRC samples were arranged as tissue microarrays and analyzed with antibodies against CA Ⅱ, CA Ⅶ, CA Ⅸ, and CA XII. Enzyme expression levels were correlated to patients’ survival and clinicopathological parameters. CA Ⅱ and CA XII staining intensities correlated with patients′ survival in that higher expression indicated poorer prognosis. The present findings indicate that CA Ⅱ and CA XII could be useful in predicting survival in CRC. |
| Publish Date |
2016-09-26 08:04 |
| Citation |
Viikilä P, Kivelä AJ, Mustonen H, Koskensalo S, Waheed A, Sly WS, Pastorek J, Pastorekova S, Parkkila S, Haglund C. Carbonic anhydrase enzymes Ⅱ, Ⅶ, Ⅸ and XII in colorectal carcinomas. World J Gastroenterol 2016; 22(36): 8168-8177 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i36/8168.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i36.8168 |
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