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Articles Published Processes
9/4/2016 2:49:00 PM | Browse: 1092 | Download: 2289
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Received |
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2016-05-05 15:53 |
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Peer-Review Started |
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2016-05-06 11:23 |
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To Make the First Decision |
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2016-06-20 10:51 |
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Return for Revision |
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2016-06-27 17:01 |
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Revised |
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2016-07-11 21:35 |
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Second Decision |
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2016-07-19 12:14 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-08-01 15:40 |
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Articles in Press |
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2016-08-01 15:41 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-08-26 08:58 |
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Publish the Manuscript Online |
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2016-09-04 14:49 |
ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was
selected by an in-house editor and fully peer-reviewed by external
reviewers. It is distributed in accordance with the Creative
Commons Attribution Non Commercial (CC BY-NC 4.0) license,
which permits others to distribute, remix, adapt, build upon this
work non-commercially, and license their derivative works on
different terms, provided the original work is properly cited and
the use is non-commercial. See: http://creativecommons.org/
licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2016. Published by Baishideng Publishing
Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Endocrinology & Metabolism |
Manuscript Type |
Basic Study |
Article Title |
Melatonin modulates adiponectin expression on murine colitis with sleep deprivation
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Manuscript Source |
Invited Manuscript |
All Author List |
Tae Kyun Kim, Young Sook Park, Haing-Woon Baik, Jin Hyun Jun, Eun Kyung Kim, Jae Woong Sull, Ho Joong Sung, Jin Woo Choi, Sook Hee Chung, Myung Chan Gye, Ju Yeon Lim, Jun Bong Kim and Seong Hwan Kim |
Funding Agency and Grant Number |
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Corresponding Author |
Young Sook Park, MD, PhD, Department of Gastroenterology, Eulji University School of Medicine, Eulji Hospital, 68 Hangeulbiseok-Ro, Nowon-Gu, Seoul 139-711, South Korea. pys1109@eulji.ac.kr |
Key Words |
Colitis; Melatonin; Adiponectin; Sleep deprivation |
Core Tip |
We report this first study that melatonin and sleep deprivation are related to adiponectin expression in the colonic mucosa of murine colitis. C57BL/6 mice were feeding with 2% DSS for inducing colitis and using specially designed multiple platform water baths for sleep deprivation. Immuno-histochemical staining and Western blot analysis was performed using anti-adiponectin antibody. The expression level of adiponectin in mucosa was decreased in colitis, with the lowest level observed in colitis combined with sleep deprivation. Melatonin injection significantly (P < 0.05) recovered the expression of adiponectin. This study suggests that melatonin and adiponectin synergistically potentiate the anti-inflammatory effects in murine colitis. |
Publish Date |
2016-09-04 14:49 |
Citation |
Kim TK, Park YS, Baik HW, Jun JH, Kim EK, Sull JW, Sung HJ, Choi JW, Chung SH, Gye MC, Lim JY, Kim JB, Kim SH. Melatonin modulates adiponectin expression on murine colitis with sleep deprivation. World J Gastroenterol 2016; 22(33): 7559-7568 |
URL |
http://www.wjgnet.com/1007-9327/full/v22/i33/7559.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v22.i33.7559 |
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