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Publication Name World Journal of Gastroenterology
Manuscript ID 27040
Country/Territory Japan
2016-05-06 09:32
Peer-Review Started
2016-05-06 11:51
To Make the First Decision
2016-06-20 10:51
Return for Revision
2016-06-27 17:03
2016-07-04 13:26
Second Decision
2016-07-19 12:14
Accepted by Journal Editor-in-Chief
2016-07-21 20:13
Accepted by Company Editor-in-Chief
2016-08-01 15:42
Articles in Press
2016-08-01 15:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-09-27 11:17
Publish the Manuscript Online
2016-10-12 14:18
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Observational Study
Article Title Pancreatic neuroendocrine tumor and solid-pseudopapillary neoplasm: Key immunohistochemical profiles for differential diagnosis
Manuscript Source Unsolicited Manuscript
All Author List Yusuke Ohara, Tatsuya Oda, Shinji Hashimoto, Yoshimasa Akashi, Ryoichi Miyamoto, Tsuyoshi Enomoto, Kaishi Satomi, Yukio Morishita and Nobuhiro Ohkohchi
Funding Agency and Grant Number
Funding Agency Grant Number
Scientific Research KAKENHI 23300362
Scientific Research KAKENHI 23659635
Corresponding Author Tatsuya Oda, MD, PhD, Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan. tatoda@md.tsukuba.ac.jp
Key Words Neuroendocrine tumor; Pancreas; Solid-pseudopapillary neoplasm; Immunohistochemistry; Diagnosis
Core Tip Neuroendocrine tumor (NET) and solid-pseudopapillary neoplasm (SPN) are two types of pancreatic tumor that were sometimes confused in differential diagnosis. We reviewed 30 pancreatic surgical specimens of NET (24 cases) and SPN (6 cases). We carried out comprehensive immunohistochemical profiling using 9 markers. E-cadherin staining in NETs, and nuclear labeling of β-catenin in SPNs were the most sensitive and specific markers. Dot-like staining of chromogranin A might indicate the possibility of SPNs rather than NETs. Moreover, two cases that had been initially diagnosed as NETs on the basis of their morphological features, demonstrated SPN-like immunohistochemical profiles.
Publish Date 2016-10-12 14:18
Citation Ohara Y, Oda T, Hashimoto S, Akashi Y, Miyamoto R, Enomoto T, Satomi K, Morishita Y, Ohkohchi N. Pancreatic neuroendocrine tumor and solid-pseudopapillary neoplasm: Key immunohistochemical profiles for differential diagnosis. World J Gastroenterol 2016; 22(38): 8596-8604
Url http://www.wjgnet.com/1007-9327/full/v22/i38/8596.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i38.8596
Full Article (PDF) WJG-22-8596.pdf
Full Article (Word) WJG-22-8596.doc
Manuscript File 27040-Review.docx
Answering Reviewers 27040-Answering reviewers.pdf
Audio Core Tip 27040-Audio core tip.mp3
Biostatistics Review Certificate 27040-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 27040-Conflict-of-interest statement.pdf
Copyright License Agreement 27040-Copyright assignment.pdf
Data Sharing Statement 27040-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 27040-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 27040-Institutional review board statement.pdf
Peer-review Report 27040-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 27040-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 27040-Scientific misconduct check.pdf
Scientific Editor Work List 27040-Scientific editor work list.pdf