Publication Name	World Journal of Hematology
Manuscript ID	27052
Country	United States

Received	2016-05-08 14:42
Peer-Review Started	2016-05-09 19:27
To Make the First Decision	2016-06-06 11:04
Return for Revision	2016-06-13 14:49
Revised	2016-06-14 04:59
Second Decision	2016-08-01 09:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-08-15 10:20
Articles in Press	2016-08-15 10:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-10-31 16:09
Publish the Manuscript Online	2016-11-03 15:47

ISSN	2218-6204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Hematology
Manuscript Type	Basic Study
Article Title	Identifying changes in punitive transcriptional factor binding sites from regulatory single nucleotide polymorphisms that are significantly associated with disease or sickness
Manuscript Source	Invited Manuscript
All Author List	Norman E Buroker
Funding Agency and Grant Number
Corresponding Author	Norman E Buroker, PhD, Department of Pediatrics, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, United States. nburoker@u.washington.edu
Key Words	Regulatory single nucleotide polymorphisms; Alleles; Transcriptional factors; Transcriptional factor binding sites; Linkage disequilibrium; Disease or sickness
Core Tip	Disease or trait-predisposing single nucleotide polymorphisms (SNPs) in or near genes can alter the transcriptional factor binding sites (TFBS) for the TFs regulating the gene; thereby affecting the health of an individual. In this report, the disease or sickness associated regulatory SNPs (rSNPs) within a sampling of nine human genes were studied with respect to the alterations in TFBS. From this sampling there were 73 punitive unique TFBS generated by the common rSNP alleles compared to 124 generated by the minor alleles indicating the tremendous diversity of potential TFs that are capable of affecting the health of person.
Publish Date	2016-11-03 15:47
Citation	Buroker NE. Identifying changes in punitive transcriptional factor binding sites from regulatory single nucleotide polymorphisms that are significantly associated with disease or sickness. World J Hematol 2016; 5(4): 75-87
URL	http://www.wjgnet.com/2218-6204/full/v5/i4/75.htm
DOI	http://dx.doi.org/10.5315/wjh.v5.i4.75

Full Article (PDF)	WJH-5-75.pdf
Full Article (Word)	WJH-5-75.doc
Manuscript File	27052-Review.docx
Answering Reviewers	27052-Answering reviewers.pdf
Audio Core Tip	27052-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	27052-Conflict-of-interest statement.pdf
Copyright License Agreement	27052-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	27052-Institutional review board statement.pdf
Peer-review Report	27052-Peer-review(s).pdf
Scientific Misconduct Check	27052-Scientific misconduct check.pdf
Scientific Editor Work List	27052-Scientific editor work list.pdf