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Articles Published Processes
11/12/2016 1:33:00 PM | Browse: 843 | Download: 1697
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Received |
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2016-05-11 09:23 |
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Peer-Review Started |
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2016-05-11 16:13 |
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To Make the First Decision |
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2016-07-13 13:30 |
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Return for Revision |
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2016-07-18 09:19 |
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Revised |
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2016-08-05 22:31 |
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Second Decision |
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2016-08-10 17:53 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-08-19 09:23 |
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Articles in Press |
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2016-08-19 09:23 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-09-01 09:52 |
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Typeset the Manuscript |
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2016-10-31 10:33 |
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Publish the Manuscript Online |
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2016-11-12 13:34 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Increased CD4+CD45RA-FoxP3low cells alter the balance between Treg and Th17 cells in colitis mice
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ya-Hui Ma, Jie Zhang, Xue Chen, You-Fu Xie, Yan-Hua Pang and Xin-Juan Liu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81300294 |
| State Scholarship Fund of China |
201509110033 |
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| Corresponding Author |
Xin-Juan Liu, PhD, MD, Department of Gastroenterology, Beijing Chaoyang Hospital, Capital Medical University, Chaoyang District, Beijing 100020, China. lxjw2012@126.com |
| Key Words |
Ulcerative colitis; Regulatory T cells; Treg cells subsets; T helper 17 cells |
| Core Tip |
The exact etiology and pathology of ulcerative colitis (UC) remains unknown. Here we investigated the role of regulatory T cell (Treg) subsets in the balance between Treg and T helper 17 (Th17) cells in various tissues from mice with dextran sulfate sodium-induced colitis. In this study we found that increased numbers of CD4+CD45RA-FoxP3low cells may cause an imbalance between Treg and Th17 cells, which was mainly localized to the lamina propria of colon rather than secondary lymphoid tissues. Based on our findings, lamina propria-resident Treg cells appear to play important roles in shaping local peripheral tolerance and maintaining intestinal homeostasis, and an imbalance of Treg and Th17 cells in the lamina propria of the colon is critical for UC pathogenesis. |
| Publish Date |
2016-11-12 13:34 |
| Citation |
Ma YH, Zhang J, Chen X, Xie YF, Pang YH, Liu XJ. Increased CD4+CD45RA-FoxP3low cells alter the balance between Treg and Th17 cells in colitis mice. World J Gastroenterol 2016; 22(42): 9356-9367 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i42/9356.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i42.9356 |
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