Publication Name	World Journal of Nephrology
Manuscript ID	2711
Country

Received	2013-03-11 08:33
Peer-Review Started	2013-03-12 11:54
To Make the First Decision	2013-03-26 11:30
Return for Revision	2013-04-01 10:43
Revised	2013-04-16 17:58
Second Decision	2013-05-18 17:00
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-05-20 00:05
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-05-28 14:34
Publish the Manuscript Online	2013-06-06 10:41

ISSN	2220-6124 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Urology & Nephrology
Manuscript Type	Brief Articles
Article Title	Hepcidin-25 negatively predicts left ventricular mass index in chronic kidney disease patients
Manuscript Source
All Author List	Yao-Peng Hsieh, Ching-Hui Huang, Chia-Ying Lee, Hung-Lin Chen, Ching-Yuang Lin and Chia-Chu Chang
Funding Agency and Grant Number
Corresponding Author	Chia-Chu Chang, MD, Division of Nephrology, Department of Internal Medicine, Changhua Christian Hospital, 135 Nanhsiao St., Changhua City 500, Taiwan. 27509@cch.org.tw
Key Words	Hepcidin-25; Ferritin; Chronic kidney disease; Left ventricular mass; Left ventricular mass index
Core Tip	Cardiovascular disease is the primary cause of death among chronic kidney disease (CKD) patients, and left ventricular hypertrophy is a powerful independent predictor of mortality for end-stage renal disease patients. Low left ventricular performance is associated with iron deficiency anemia in rats with CKD. Hepcidin-25, a recently discovered biologically active 25-amino acid peptide, plays a key role in the iron homeostasis. Chronic iron deficiency may, by itself, reduce exercise capacity and cause ultrastructural alterations in cardiomyocytes. In the study, we showed that patients in higher grade of CKD stage had the higher serum hepcidin levels, and that there was negative correlation between serum hepcidin level and LVMI.
Publish Date	2013-06-06 10:41
Citation	Hsieh YP, Huang CH, Lee CY, Chen HL, Lin CY, Chang CC. Hepcidin-25 negatively predicts left ventricular mass index in chronic kidney disease patients. World J Nephrol 2013; 2(2): 38-43
URL	http://www.wjgnet.com/2220-6124/full/v2/i2/38.htm
DOI	http://dx.doi.org/10.5527/wjn.v2.i2.38

Full Article (PDF)	WJN-2-38.pdf
Manuscript File	2711-Review.doc
Answering Reviewers	2711-Answering reviewers.doc
Copyright License Agreement	2711-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	2711-Language certificate.pdf
Peer-review Report	2711-Peer review(s).pdf
Scientific Editor Work List	2711-Scientific editor work list.doc