Publication Name	World Journal of Gastroenterology
Manuscript ID	2713
Country	China

Received	2013-03-11 08:41
Peer-Review Started	2013-03-12 12:09
First Decision by Editorial Office Director
Return for Revision	2013-04-17 12:54
Revised	2013-04-24 16:01
Publication Fee Transferred
Second Decision by Editor	2013-05-09 13:03
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-05-10 10:54
Articles in Press
Edit the Manuscript by Language Editor	2013-06-03 21:54
Typeset the Manuscript	2013-06-27 16:36
Publish the Manuscript Online	2013-06-28 23:55

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Case Report
Article Title	Severe irinotecan-induced toxicity in a patient with UGT1A1*28 and UGT1A1*6 polymorphisms
Manuscript Source	Invited Manuscript
All Author List	Jian-Ming Xu, Yan Wang, Fei-Jiao Ge, Li Lin, Ze-Yuan Liu and Manish R Sharma
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation Project 30971579 Capital Development Foundation 2007-2029
Corresponding Author	Jian-Ming Xu, MD, Department of GI Oncology, Affiliated Hospital Cancer Center, Academy of Military Medical Sciences, No. 8 Dongda Avenue, Fengtai District, Beijing 100071, China. jmxu2003@yahoo.com
Key Words	Irinotecan; Toxicity; UGT1A1*28; UGT1A1*6; Polymorphism
Core Tip	This is the first reported case. This patient with heterozygous UGT1A1*28 and UGT1A1*6 polymorphisms experienced two dose reductions of irinotecan due to severe toxicity according to pharmacokinetic analyses of SN-38 and SN-38 glucuronide levels. It seems that this patient benefited from a longer treatment duration, suggesting that irinotecan dose individualization for mutant metastatic colorectal cancer patients with heterozygous UGT1A1*28 or UGT1A1*6 polymorphisms may be warranted.
Publish Date	2013-06-28 23:55
Citation	Xu JM, Wang Y, Ge FJ, Lin L, Liu ZY, Sharma MR. Severe irinotecan-induced toxicity in a patient with UGT1A1*28 and UGT1A1*6 polymorphisms. World J Gastroenterol 2013; 19(24): 3899-3903
URL	http://www.wjgnet.com/1007-9327/full/v19/i24/3899.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i24.3899

Full Article (PDF)	WJG-19-3899.pdf
Manuscript File	2713-Review.doc
Answering Reviewers	2713-Answering reviewers.pdf
Copyright License Agreement	2713-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	2713-Language certificate.pdf
Peer-review Report	2713-Peer reviews.pdf
Scientific Editor Work List	2713-Scientific editor work list.doc