Publication Name	World Journal of Hepatology
Manuscript ID	27140
Country	Brazil

Received	2016-05-13 09:04
Peer-Review Started	2016-05-16 14:03
To Make the First Decision	2016-06-07 13:55
Return for Revision	2016-06-14 11:15
Revised	2016-06-22 00:00
Second Decision	2016-08-01 09:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-08-16 14:15
Articles in Press	2016-08-16 14:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-10-11 18:14
Publish the Manuscript Online	2016-10-14 13:37

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Control Study
Article Title	Polymorphisms of folate metabolism genes in patients with cirrhosis and hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Nathália Perpétua Peres, Ana Lívia Silva Galbiatti-Dias, Márcia Maria Urbanin Castanhole-Nunes, Renato Ferreira da Silva, Érika Cristina Pavarino, Eny Maria Goloni-Bertollo and Mariangela Torreglosa Ruiz-Cintra
Funding Agency and Grant Number
Corresponding Author	Eny Maria Goloni-Bertollo, MD, São José do Rio Preto Medical School, FAMERP and Medical School Fundation, FUNFARME, Av. Brigadeiro Faria Lima, 5416, São José do Rio Preto 15090-000, Brazil. eny.goloni@famerp.br
Key Words	Polymorphism; Folate metabolism; Liver cirrhosis; Hepatocellular carcinoma
Core Tip	Our study is relevant because we can get better understanding on the mechanisms involved in the development of hepatocellular and Cirrhosis Carcinoma and folate metabolism. It is already known that polymorphisms cause DNA hypomethylation, which cause abnormal changes in gene expression inactivating suppressor genes tumor. In this study we have found some positive associations which was possible to understand the carcinogenesis of this tumor and offer new possibilities for diagnosis. Throughout these results it is possible to achieve better quality of life in early treatments.
Publish Date	2016-10-14 13:37
Citation	Peres NP, Galbiatti-Dias ALS, Castanhole-Nunes MMU, da Silva RF, Pavarino ÉC, Goloni-Bertollo EM, Ruiz-Cintra MT. Polymorphisms of folate metabolism genes in patients with cirrhosis and hepatocellular carcinoma. World J Hepatol 2016; 8(29): 1234-1243
URL	http://www.wjgnet.com/1948-5182/full/v8/i29/1234.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i29.1234

Full Article (PDF)	WJH-8-1234.pdf
Full Article (Word)	WJH-8-1234.doc
Manuscript File	27140-Review.doc
Answering Reviewers	27140-Answering reviewers.pdf
Audio Core Tip	27140-Audio core tip.mp3
Biostatistics Review Certificate	27140-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	27140-Conflict-of-interest statement.pdf
Copyright License Agreement	27140-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	27140-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	27140-Language certificate.pdf
Peer-review Report	27140-Peer-review(s).pdf
Scientific Misconduct Check	27140-Scientific misconduct check.pdf
Scientific Editor Work List	27140-Scientific editor work list.pdf