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Articles Published Processes
8/23/2016 6:33:00 PM | Browse: 1160 | Download: 1234
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Received |
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2016-05-13 08:42 |
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Peer-Review Started |
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2016-05-16 18:54 |
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To Make the First Decision |
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2016-06-20 09:03 |
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Return for Revision |
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2016-06-20 16:33 |
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Revised |
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2016-07-11 20:35 |
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Second Decision |
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2016-07-21 10:15 |
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Accepted by Journal Editor-in-Chief |
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2016-07-22 00:53 |
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Accepted by Executive Editor-in-Chief |
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2016-08-01 14:15 |
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Articles in Press |
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2016-08-01 14:15 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-08-18 10:28 |
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Publish the Manuscript Online |
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2016-08-24 10:09 |
ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Oncology |
Manuscript Type |
Review |
Article Title |
Changes in cellular mechanical properties during onset or progression of colorectal cancer
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Manuscript Source |
Invited Manuscript |
All Author List |
Gabriele Ciasca, Massimiliano Papi, Eleonora Minelli, Valentina Palmieri and Marco De Spirito |
Funding Agency and Grant Number |
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Corresponding Author |
Dr. Massimiliano Papi, Professor, Institute of Physics, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Roma, Italy. massimiliano.papi@unicatt.it |
Key Words |
Colorectal cancer; Biomechanics; Pressure; Mechanical signalling; Atomic force microscopy; Wnt |
Core Tip |
Physical forces, either within tissues or externally applied, affect all tissues of the body. Cell mechanotransduction converts such forces into cellular responses that affect gene expression, protein synthesis, proliferation and morphogenesis. Here, we focused on recent studies covering the impact of physical stimuli such as compression, shear stress, adhesion and stiffness, in the development of colorectal cancer. We highlight that such stimuli play a major role in the tumor progression, affecting the Wnt pathway, being involved in the differentiation of non-invasive cells into metastatic variants and helping metastatic cells to survive the mechanical stress associated with intravasation, circulation and extravasation. |
Publish Date |
2016-08-24 10:09 |
Citation |
Ciasca G, Papi M, Minelli E, Palmieri V, De Spirito M. Changes in cellular mechanical properties during onset or progression of colorectal cancer. World J Gastroenterol 2016; 22(32): 7203-7214 |
URL |
http://www.wjgnet.com/1007-9327/full/v22/i32/7203.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v22.i32.7203 |
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