Publication Name	World Journal of Gastroenterology
Manuscript ID	27145
Country	Italy

Received	2016-05-13 08:42
Peer-Review Started	2016-05-16 18:54
To Make the First Decision	2016-06-20 09:03
Return for Revision	2016-06-20 16:33
Revised	2016-07-11 20:35
Second Decision	2016-07-21 10:15
Accepted by Journal Editor-in-Chief	2016-07-22 00:53
Accepted by Company Editor-in-Chief	2016-08-01 14:15
Articles in Press	2016-08-01 14:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-08-18 10:28
Publish the Manuscript Online	2016-08-24 10:09

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Review
Article Title	Changes in cellular mechanical properties during onset or progression of colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Gabriele Ciasca, Massimiliano Papi, Eleonora Minelli, Valentina Palmieri and Marco De Spirito
Funding Agency and Grant Number
Corresponding Author	Dr. Massimiliano Papi, Professor, Institute of Physics, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Roma, Italy. massimiliano.papi@unicatt.it
Key Words	Colorectal cancer; Biomechanics; Pressure; Mechanical signalling; Atomic force microscopy; Wnt
Core Tip	Physical forces, either within tissues or externally applied, affect all tissues of the body. Cell mechanotransduction converts such forces into cellular responses that affect gene expression, protein synthesis, proliferation and morphogenesis. Here, we focused on recent studies covering the impact of physical stimuli such as compression, shear stress, adhesion and stiffness, in the development of colorectal cancer. We highlight that such stimuli play a major role in the tumor progression, affecting the Wnt pathway, being involved in the differentiation of non-invasive cells into metastatic variants and helping metastatic cells to survive the mechanical stress associated with intravasation, circulation and extravasation.
Publish Date	2016-08-24 10:09
Citation	Ciasca G, Papi M, Minelli E, Palmieri V, De Spirito M. Changes in cellular mechanical properties during onset or progression of colorectal cancer. World J Gastroenterol 2016; 22(32): 7203-7214
URL	http://www.wjgnet.com/1007-9327/full/v22/i32/7203.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i32.7203

Full Article (PDF)	WJG-22-7203.pdf
Full Article (Word)	WJG-22-7203.doc
Manuscript File	27145-Review.docx
Answering Reviewers	27145-Answering reviewers.pdf
Audio Core Tip	27145-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	27145-Conflict-of-interest statement.pdf
Copyright License Agreement	27145-Copyright assignment.pdf
Peer-review Report	27145-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	27145-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	27145-Scientific misconduct check.pdf
Scientific Editor Work List	27145-Scientific editor work list.pdf