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8/23/2016 6:33:00 PM | Browse: 623 | Download: 584
Publication Name World Journal of Gastroenterology
Manuscript ID 27145
Country/Territory Italy
Received
2016-05-13 08:42
Peer-Review Started
2016-05-16 18:54
To Make the First Decision
2016-06-20 09:03
Return for Revision
2016-06-20 16:33
Revised
2016-07-11 20:35
Second Decision
2016-07-21 10:15
Accepted by Journal Editor-in-Chief
2016-07-22 00:53
Accepted by Company Editor-in-Chief
2016-08-01 14:15
Articles in Press
2016-08-01 14:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-08-18 10:28
Publish the Manuscript Online
2016-08-24 10:09
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Review
Article Title Changes in cellular mechanical properties during onset or progression of colorectal cancer
Manuscript Source Invited Manuscript
All Author List Gabriele Ciasca, Massimiliano Papi, Eleonora Minelli, Valentina Palmieri and Marco De Spirito
Funding Agency and Grant Number
Corresponding Author Dr. Massimiliano Papi, Professor, Institute of Physics, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Roma, Italy. massimiliano.papi@unicatt.it
Key Words Colorectal cancer; Biomechanics; Pressure; Mechanical signalling; Atomic force microscopy; Wnt
Core Tip Physical forces, either within tissues or externally applied, affect all tissues of the body. Cell mechanotransduction converts such forces into cellular responses that affect gene expression, protein synthesis, proliferation and morphogenesis. Here, we focused on recent studies covering the impact of physical stimuli such as compression, shear stress, adhesion and stiffness, in the development of colorectal cancer. We highlight that such stimuli play a major role in the tumor progression, affecting the Wnt pathway, being involved in the differentiation of non-invasive cells into metastatic variants and helping metastatic cells to survive the mechanical stress associated with intravasation, circulation and extravasation.
Publish Date 2016-08-24 10:09
Citation Ciasca G, Papi M, Minelli E, Palmieri V, De Spirito M. Changes in cellular mechanical properties during onset or progression of colorectal cancer. World J Gastroenterol 2016; 22(32): 7203-7214
URL http://www.wjgnet.com/1007-9327/full/v22/i32/7203.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i32.7203
Full Article (PDF) WJG-22-7203.pdf
Full Article (Word) WJG-22-7203.doc
Manuscript File 27145-Review.docx
Answering Reviewers 27145-Answering reviewers.pdf
Audio Core Tip 27145-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 27145-Conflict-of-interest statement.pdf
Copyright License Agreement 27145-Copyright assignment.pdf
Peer-review Report 27145-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 27145-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 27145-Scientific misconduct check.pdf
Scientific Editor Work List 27145-Scientific editor work list.pdf