Publication Name	World Journal of Hepatology
Manuscript ID	27149
Country	United States

Received	2016-05-13 16:17
Peer-Review Started	2016-05-14 11:19
First Decision by Editorial Office Director
Return for Revision	2016-06-14 11:24
Revised	2016-06-28 03:43
Publication Fee Transferred
Second Decision by Editor	2016-08-08 15:24
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2016-08-16 14:16
Articles in Press	2016-08-16 14:16
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-10-30 20:48
Publish the Manuscript Online	2016-11-04 10:35

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Liver resection for early hepatocellular cancer: Comparison of centers in 3 different countries
Manuscript Source	Unsolicited Manuscript
All Author List	Linda L Wong, Brenda Y Hernandez, Yurii B Shvetsov, Yoichi Kawano, Zhao-You Tang and Jun-Fang Ji
Funding Agency and Grant Number
Corresponding Author	Linda L Wong, MD, Professor, Cancer Center, Department of Surgery, John A Burns School of Medicine, University of Hawaii, 550 South Beretania Street, Suite 403, Honolulu, HI 96813, United States. hepatoma@aol.com
Key Words	Hepatocellular cancer; Liver resection; Viral hepatitis
Core Tip	Treatment for hepatocellular cancer (HCC) depends on stage and liver function. Single-institution studies have characterized resection for HCC but this unique study combines the experience of three large hepatobiliary centers in different countries with 573 resections for stage?Ⅰ/Ⅱ HCC in Tokyo (<i>n</i> = 250), Honolulu (<i>n</i> = 146) and Shanghai (<i>n</i> = 177). Groups differed in viral hepatitis, tumor size, alpha fetal protein (AFP) and cirrhosis. One and 5-year mortality was lowest in the Tokyo cohort. Elevated AFP, low albumin, tumor > 5 cm and cirrhosis were independently-associated with increased 5-year mortality. The profile of early-stage HCC patients is strikingly different across countries and likely contributes to survival differences.
Publish Date	2016-11-04 10:35
Citation	Wong LL, Hernandez BY, Shvetsov YB, Kawano Y, Tang ZY, Ji JF. Liver resection for early hepatocellular cancer: Comparison of centers in 3 different countries. World J Hepatol 2016; 8(31): 1327-1335
URL	http://www.wjgnet.com/1948-5182/full/v8/i31/1327.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i31.1327

Full Article (PDF)	WJH-8-1327.pdf
Full Article (Word)	WJH-8-1327.doc
Manuscript File	27149-Review.docx
Answering Reviewers	27149-Answering reviewers.pdf
Audio Core Tip	27149-Audio core tip.mp3
Biostatistics Review Certificate	Biostatistics_Statement_20160513094226.docx
Conflict-of-Interest Disclosure Form	27149-Conflict-of-interest statement.pdf
Copyright License Agreement	27149-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	27149-Institutional review board statement.pdf
Peer-review Report	27149-Peer-review(s).pdf
Scientific Misconduct Check	27149-Scientific misconduct check.pdf
Scientific Editor Work List	27149-Scientific editor work list.pdf