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10/12/2016 2:18:00 PM | Browse: 944 | Download: 1458
Publication Name World Journal of Gastroenterology
Manuscript ID 27251
Country/Territory China
Received
2016-05-19 17:06
Peer-Review Started
2016-05-20 11:46
To Make the First Decision
2016-07-12 15:47
Return for Revision
2016-07-15 15:25
Revised
2016-07-29 09:36
Second Decision
2016-08-17 09:33
Accepted by Journal Editor-in-Chief
2016-08-17 14:42
Accepted by Company Editor-in-Chief
2016-08-19 09:20
Articles in Press
2016-08-19 09:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
2016-08-28 18:54
Typeset the Manuscript
2016-09-27 09:16
Publish the Manuscript Online
2016-10-12 14:18
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Basic Study
Article Title Special AT-rich sequence-binding protein 2 acts as a negative regulator of stemness in colorectal cancer cells
Manuscript Source Unsolicited Manuscript
All Author List Ying Li, Yu-Hong Liu, Yu-Ying Hu, Lin Chen and Jian-Ming Li
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81525020
National Natural Science Foundation of China 81502033
National Natural Science Foundation of China 81272300
National Natural Science Foundation of China 31570753
Corresponding Author Jian-Ming Li, MD, PhD, DSc, Professor, Chief, Department of Pathology, Nanfang Hospital, Southern Medical University, No. 1838 Guangzhou Road North, Guangzhou 510515, Guangdong Province, China. lixinyue@fimmu.com
Key Words Special AT-rich sequence-binding protein 2; Colorectal cancer; Stemness; Metastasis
Core Tip We found that special AT-rich sequence-binding protein 2 (SATB2) had a suppressive effect on the tumor growth, adhesion and migration in vitro. Moreover, SATB2 could negatively regulate the stemness of colorectal cancer (CRC) cells by directly binding to the regulatory elements in the genetic loci of several stem cell markers. Our study provides a new mechanism for the involvement of SATB2 in CRC progression and helps us to better understand the metastasis traits of cancer stem cells.
Publish Date 2016-10-12 14:18
Citation Li Y, Liu YH, Hu YY, Chen L, Li JM. Special AT-rich sequence-binding protein 2 acts as a negative regulator of stemness in colorectal cancer cells. World J Gastroenterol 2016; 22(38): 8528-8539
URL http://www.wjgnet.com/1007-9327/full/v22/i38/8528.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i38.8528
Full Article (PDF) WJG-22-8528.pdf
Full Article (Word) WJG-22-8528.doc
Manuscript File 27251-Review.docx
Answering Reviewers 27251-Answering reviewers.pdf
Audio Core Tip 27251-Audio core tip.mp3
Biostatistics Review Certificate 27251-Biostatistics statement .pdf
Conflict-of-Interest Disclosure Form 27251-Conflict-of-interest statement.pdf
Copyright License Agreement 27251-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 27251-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 27251-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 27251-Language certificate.pdf
Supplementary Material Supplementary_Material_20160519161350.docx
Peer-review Report 27251-Peer-review(s).pdf
Scientific Misconduct Check 27251-Scientific research process.pdf