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Articles Published Processes
10/12/2016 2:18:00 PM | Browse: 1079 | Download: 1899
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Received |
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2016-05-19 17:06 |
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Peer-Review Started |
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2016-05-20 11:46 |
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To Make the First Decision |
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2016-07-12 15:47 |
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Return for Revision |
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2016-07-15 15:25 |
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Revised |
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2016-07-29 09:36 |
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Second Decision |
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2016-08-17 09:33 |
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Accepted by Journal Editor-in-Chief |
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2016-08-17 14:42 |
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Accepted by Executive Editor-in-Chief |
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2016-08-19 09:20 |
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Articles in Press |
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2016-08-19 09:20 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-08-28 18:54 |
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Typeset the Manuscript |
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2016-09-27 09:16 |
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Publish the Manuscript Online |
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2016-10-12 14:18 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Special AT-rich sequence-binding protein 2 acts as a negative regulator of stemness in colorectal cancer cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ying Li, Yu-Hong Liu, Yu-Ying Hu, Lin Chen and Jian-Ming Li |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81525020 |
| National Natural Science Foundation of China |
81502033 |
| National Natural Science Foundation of China |
81272300 |
| National Natural Science Foundation of China |
31570753 |
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| Corresponding Author |
Jian-Ming Li, MD, PhD, DSc, Professor, Chief, Department of Pathology, Nanfang Hospital, Southern Medical University, No. 1838 Guangzhou Road North, Guangzhou 510515, Guangdong Province, China. lixinyue@fimmu.com |
| Key Words |
Special AT-rich sequence-binding protein 2; Colorectal cancer; Stemness; Metastasis |
| Core Tip |
We found that special AT-rich sequence-binding protein 2 (SATB2) had a suppressive effect on the tumor growth, adhesion and migration in vitro. Moreover, SATB2 could negatively regulate the stemness of colorectal cancer (CRC) cells by directly binding to the regulatory elements in the genetic loci of several stem cell markers. Our study provides a new mechanism for the involvement of SATB2 in CRC progression and helps us to better understand the metastasis traits of cancer stem cells. |
| Publish Date |
2016-10-12 14:18 |
| Citation |
Li Y, Liu YH, Hu YY, Chen L, Li JM. Special AT-rich sequence-binding protein 2 acts as a negative regulator of stemness in colorectal cancer cells. World J Gastroenterol 2016; 22(38): 8528-8539 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i38/8528.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i38.8528 |
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