| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
|
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
DNA methylation of angiotensin Ⅱ receptor gene in nonalcoholic steatohepatitis-related liver fibrosis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Kiyoshi Asada, Yosuke Aihara, Hiroaki Takaya, Ryuichi Noguchi, Tadashi Namisaki, Kei Moriya, Masakazu Uejima, Mitsuteru Kitade, Tsuyoshi Mashitani, Kosuke Takeda, Hideto Kawaratani, Yasushi Okura, Kosuke Kaji, Akitoshi Douhara, Yasuhiko Sawada, Norihisa Nishimura, Kenichiro Seki, Akira Mitoro, Junichi Yamao and Hitoshi Yoshiji |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Kiyoshi Asada, MD, PhD, Research Scientist, Third Department of Internal Medicine, Nara Medical University, 840 Shijocho, Kashihara, Nara 634-8521,
Japan. kasada@naramed-u.ac.jp |
| Key Words |
Epigenetics; DNA methylation; Angiotensin Ⅱ receptor; Liver fibrosis; Nonalcoholic steatohepatitis |
| Core Tip |
We report the first study to show that Agtr1a methylation occurred during the development of no-nalcoholic steatohepatitis-related liver fibrosis. Inter-estingly, Agtr1a gene expression was upregulated during liver fibrosis, although Agtr1a was methylated. This study demonstrates for the first time that renin-angiotensin system-related gene expression is regulated by DNA methylation during liver fibrosis. This finding raises ex-pectations about the therapeutic application of deme-thylating agents for the treatment of liver fibrosis. |
| Publish Date |
2016-09-28 16:37 |
| Citation |
Asada K, Aihara Y, Takaya H, Noguchi R, Namisaki T, Moriya K, Uejima M, Kitade M, Mashitani T, Takeda K, Kawaratani H, Okura Y, Kaji K, Douhara A, Sawada Y, Nishimura N, Seki K, Mitoro A, Yamao J, Yoshiji H. DNA methylation of angiotensin Ⅱ receptor gene in nonalcoholic steatohepatitis-related liver fibrosis. World J Hepatol 2016; 8(28): 1194-1199 |
| URL |
http://www.wjgnet.com/1948-5182/full/v8/i28/1194.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v8.i28.1194 |
