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9/28/2016 4:37:00 PM | Browse: 378 | Download: 506
Publication Name World Journal of Hepatology
Manuscript ID 27269
Country/Territory Japan
Received
2016-05-20 16:47
Peer-Review Started
2016-05-21 21:22
To Make the First Decision
2016-07-04 16:49
Return for Revision
2016-07-05 14:13
Revised
2016-07-08 23:09
Second Decision
2016-07-27 15:26
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-08-29 11:59
Articles in Press
2016-08-29 11:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-09-22 14:53
Publish the Manuscript Online
2016-09-28 16:37
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title DNA methylation of angiotensin Ⅱ receptor gene in nonalcoholic steatohepatitis-related liver fibrosis
Manuscript Source Unsolicited Manuscript
All Author List Kiyoshi Asada, Yosuke Aihara, Hiroaki Takaya, Ryuichi Noguchi, Tadashi Namisaki, Kei Moriya, Masakazu Uejima, Mitsuteru Kitade, Tsuyoshi Mashitani, Kosuke Takeda, Hideto Kawaratani, Yasushi Okura, Kosuke Kaji, Akitoshi Douhara, Yasuhiko Sawada, Norihisa Nishimura, Kenichiro Seki, Akira Mitoro, Junichi Yamao and Hitoshi Yoshiji
Funding Agency and Grant Number
Corresponding author Kiyoshi Asada, MD, PhD, Research Scientist, Third Department of Internal Medicine, Nara Medical University, 840 Shijocho, Kashihara, Nara 634-8521, Japan. kasada@naramed-u.ac.jp
Keywords Epigenetics; DNA methylation; Angiotensin Ⅱ receptor; Liver fibrosis; Nonalcoholic steatohepatitis
Core Tip We report the first study to show that Agtr1a methylation occurred during the development of no-nalcoholic steatohepatitis-related liver fibrosis. Inter-estingly, Agtr1a gene expression was upregulated during liver fibrosis, although Agtr1a was methylated. This study demonstrates for the first time that renin-angiotensin system-related gene expression is regulated by DNA methylation during liver fibrosis. This finding raises ex-pectations about the therapeutic application of deme-thylating agents for the treatment of liver fibrosis.
Publish Date 2016-09-28 16:37
Citation Asada K, Aihara Y, Takaya H, Noguchi R, Namisaki T, Moriya K, Uejima M, Kitade M, Mashitani T, Takeda K, Kawaratani H, Okura Y, Kaji K, Douhara A, Sawada Y, Nishimura N, Seki K, Mitoro A, Yamao J, Yoshiji H. DNA methylation of angiotensin Ⅱ receptor gene in nonalcoholic steatohepatitis-related liver fibrosis. World J Hepatol 2016; 8(28): 1194-1199
Url http://www.wjgnet.com/1948-5182/full/v8/i28/1194.htm
DOI http://dx.doi.org/10.4254/wjh.v8.i28.1194
Full Article (PDF) WJH-8-1194.pdf
Full Article (Word) WJH-8-1194.doc
Manuscript File 27269-Review.docx
Answering Reviewers 27269-Answering reviewers.pdf
Audio Core Tip 27269-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 27269-Conflict-of-interest statement.pdf
Copyright License Agreement 27269-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 27269-Institutional animal care and use comittee statement.pdf
Non-Native Speakers of English Editing Certificate 27269-Language certificate.pdf
Peer-review Report 27269-Peer-review(s).pdf
Scientific Misconduct Check 27269-Scientific misconduct check.pdf
Scientific Editor Work List 27269-Scientific editor work list.pdf