Publication Name	World Journal of Gastroenterology
Manuscript ID	27279
Country	Thailand

Received	2016-05-22 14:01
Peer-Review Started	2016-05-23 10:38
To Make the First Decision	2016-06-20 09:22
Return for Revision	2016-06-21 09:39
Revised	2016-07-04 10:41
Second Decision	2016-07-18 09:01
Accepted by Journal Editor-in-Chief	2016-07-21 06:34
Accepted by Executive Editor-in-Chief	2016-08-01 15:30
Articles in Press	2016-08-01 15:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-09-27 15:43
Publish the Manuscript Online	2016-09-30 18:06

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Biochemistry & Molecular Biology
Manuscript Type	Basic Study
Article Title	Increased ATG5-ATG12 in hepatitis B virus-associated hepatocellular carcinoma and their role in apoptosis
Manuscript Source	Unsolicited Manuscript
All Author List	Areerat Kunanopparat, Ingorn Kimkong, Tanapat Palaga, Pisit Tangkijvanich, Boonchoo Sirichindakul and Nattiya Hirankarn
Funding Agency and Grant Number	Funding Agency Grant Number National Research Council of Thailand 2013 International Research Integration, Chula Research Scholar, Ratchadaphiseksomphot Endowment Fund, Center of Excellence in Immunology and Immune-mediated Diseases and the Rachadapisaek Sompote Post-Doctoral Fund, Chulalongkorn University Ratchadaphiseksomphot Matching Fund from the Faculty of Medicine, Chulalongkorn University
Corresponding Author	Dr. Ingorn Kimkong, Assistant Professor, Department of Microbiology, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand. fsciiok@ku.ac.th
Key Words	Autophagy; Hepatitis B virus; Hepatocellular carcinoma; ATG12; Apoptosis; Cell cycle; Notch signaling
Core Tip	ATG5-ATG12 protein expression was increased in hepatitis B virus (HBV)-transfected HepG2.2.15 cells when they were compared with HepG2 cells and was increased in tumor liver tissues compared to adjacent non-tumor tissues from hepatocellular carcinoma (HCC) patients with HBV infection. We showed that silencing of ATG12 increased cell apoptosis of HepG2.2.15 cells but not HepG2 cells under starvation conditions. These results suggest that ATG5-ATG12 proteins are important for the survival of HBV-associated HCC during states of limited tumor nutrients. The inhibition of ATG12 might be a good target for HBV-associated HCC treatment.
Publish Date	2016-09-30 18:06
Citation	Kunanopparat A, Kimkong I, Palaga T, Tangkijvanich P, Sirichindakul B, Hirankarn N. Increased ATG5-ATG12 in hepatitis B virus-associated hepatocellular carcinoma and their role in apoptosis. World J Gastroenterol 2016; 22(37): 8361-8374
URL	http://www.wjgnet.com/1007-9327/full/v22/i37/8361.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i37.8361

Full Article (PDF)	WJG-22-8361.pdf
Full Article (Word)	WJG-22-8361.doc
Manuscript File	27279-Review.docx
Answering Reviewers	27279-Answering reviewers.pdf
Audio Core Tip	27279-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	27279-Conflict-of-interest statement.pdf
Copyright License Agreement	27279-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	27279-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	27279-Language certificate.pdf
Peer-review Report	27279-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	27279-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	27279-Scientific misconduct check.pdf
Scientific Editor Work List	27279-Scientific editor work list.pdf