Publication Name	World Journal of Stem Cells
Manuscript ID	27305
Country	United States

Received	2016-05-23 09:24
Peer-Review Started	2016-05-23 10:39
To Make the First Decision	2016-07-04 15:43
Return for Revision	2016-07-06 08:26
Revised	2016-08-11 10:38
Second Decision	2016-08-19 09:14
Accepted by Journal Editor-in-Chief	2016-08-22 08:57
Accepted by Executive Editor-in-Chief	2016-08-29 11:45
Articles in Press	2016-08-29 11:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-10-17 14:17
Publish the Manuscript Online	2016-10-20 21:54

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Hematology
Manuscript Type	Review
Article Title	Update on acute myeloid leukemia stem cells: New discoveries and therapeutic opportunities
Manuscript Source	Invited Manuscript
All Author List	Maximilian Stahl, Tae Kon Kim and Amer M Zeidan
Funding Agency and Grant Number
Corresponding Author	Amer M Zeidan, MBBS, Assistant Professor, Section of Hematology, Department of Internal Medicine, Yale School of Medicine, 300 George Street, New Haven, CT 06510-3222, United States. amer.zeidan@yale.edu
Key Words	Leukemia stem cells; Cancer stem cells; Acute myeloid leukemia; Stem cell niche; Xenotrans­plantation; Plerixafor; NF-kB; C-X-C chemokine receptor type 4
Core Tip	Leukemia stem cell (LSC) directed therapy targets: (1) Cell surface markers expressed on LSC: CD33, CD44, CD123, CD47, etc.; (2) Crucial pathways for maintenance of their stemness: NF-κB, PI3K/AKT/mTOR and bcl-2; and (3) Interactions between LSC in the bone marrow niche: LSC mobilization with granulocyte-colony stimulating factor and inhibition of LSC homing to the bone marrow by interrupting the C-X-C chemokine receptor type 4-CXCL12 and VCAM-VLA4 axis.
Publish Date	2016-10-20 21:54
Citation	Stahl M, Kim TK, Zeidan AM. Update on acute myeloid leukemia stem cells: New discoveries and therapeutic opportuni­ties. World J Stem Cells 2016; 8(10): 316-331
URL	http://www.wjgnet.com/1948-0210/full/v8/i10/316.htm
DOI	http://dx.doi.org/10.4252/wjsc.v8.i10.316

Full Article (PDF)	WJSC-8-316.pdf
Full Article (Word)	WJSC-8-316.doc
Manuscript File	27305-Review.docx
Answering Reviewers	27305-Answering reviewers.pdf
Audio Core Tip	27305-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	27305-Conflict-of-interest statement.pdf
Copyright License Agreement	27305-Copyright assignment.pdf
Peer-review Report	27305-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	27305-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	27305-Scientific misconduct check.pdf
Scientific Editor Work List	27305-Scientific editor work list.pdf