Publication Name	World Journal of Stem Cells
Manuscript ID	27369
Country	Japan

Received	2016-05-27 09:53
Peer-Review Started	2016-05-27 16:00
To Make the First Decision	2016-07-04 15:48
Return for Revision	2016-07-06 08:50
Revised	2016-07-12 11:54
Second Decision	2016-07-14 15:08
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-07-22 11:59
Articles in Press	2016-07-22 12:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-09-13 13:17
Publish the Manuscript Online	2016-09-19 15:28

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/S
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Minireviews
Article Title	Stem cell-derived exosomes as a therapeutic tool for cardiovascular disease
Manuscript Source	Invited Manuscript
All Author List	Etsu Suzuki, Daishi Fujita, Masao Takahashi, Shigeyoshi Oba and Hiroaki Nishimatsu
Funding Agency and Grant Number
Corresponding Author	Etsu Suzuki, MD, PhD, Institute of Medical Science, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki 216-8512, Japan. esuzuki-tky@umin.ac.jp
Key Words	Exosomes; Messenger RNA; Cardiovascular disease; Mesenchymal stem cells; Stem cells; MicroRNA
Core Tip	Exosomes are membrane vesicles that contain and transport specific bioactive molecules, such as proteins, messenger RNAs, and microRNAs, to recipient cells. In this review, we describe the mechanisms of exosome biogenesis, selective sorting of bioactive molecules into exosomes, and exosome secretion. We also discuss preclinical studies in which stem cell-derived exosomes were successfully used to treat cardiovascular disease (CVD). Finally, we discuss the future possibility of exosome-based clinical treatment of CVD.
Publish Date	2016-09-19 15:28
Citation	Suzuki E, Fujita D, Takahashi M, Oba S, Nishimatsu H. Stem cell-derived exosomes as a therapeutic tool for cardiovascular disease. World J Stem Cells 2016; 8(9): 297-305
URL	http://www.wjgnet.com/1948-0210/full/v8/i9/297.htm
DOI	http://dx.doi.org/10.4252/wjsc.v8.i9.297

Full Article (PDF)	WJSC-8-297.pdf
Full Article (Word)	WJSC-8-297.doc
Manuscript File	27369-Review.docx
Answering Reviewers	27369-Answering reviewers.pdf
Audio Core Tip	27369-Audio core tip.wav
Conflict-of-Interest Disclosure Form	27369-Conflict-of-interest statement.pdf
Copyright License Agreement	27369-Copyright assignment.pdf
Peer-review Report	27369-Peer-review(s).pdf
Scientific Misconduct Check	27369-Scientific misconduct check.pdf
Scientific Editor Work List	27369-Scientific editor work list.pdf