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9/19/2016 3:28:00 PM | Browse: 1240 | Download: 1503
Publication Name World Journal of Stem Cells
Manuscript ID 27369
Country/Territory Japan
Received
2016-05-27 09:53
Peer-Review Started
2016-05-27 16:00
To Make the First Decision
2016-07-04 15:48
Return for Revision
2016-07-06 08:50
Revised
2016-07-12 11:54
Second Decision
2016-07-14 15:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-07-22 11:59
Articles in Press
2016-07-22 12:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-09-13 13:17
Publish the Manuscript Online
2016-09-19 15:28
ISSN 1948-0210 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/S
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cardiac & Cardiovascular Systems
Manuscript Type Minireviews
Article Title Stem cell-derived exosomes as a therapeutic tool for cardiovascular disease
Manuscript Source Invited Manuscript
All Author List Etsu Suzuki, Daishi Fujita, Masao Takahashi, Shigeyoshi Oba and Hiroaki Nishimatsu
Funding Agency and Grant Number
Corresponding Author Etsu Suzuki, MD, PhD, Institute of Medical Science, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki 216-8512, Japan. esuzuki-tky@umin.ac.jp
Key Words Exosomes; Messenger RNA; Cardiovascular disease; Mesenchymal stem cells; Stem cells; MicroRNA
Core Tip Exosomes are membrane vesicles that contain and transport specific bioactive molecules, such as proteins, messenger RNAs, and microRNAs, to recipient cells. In this review, we describe the mechanisms of exosome biogenesis, selective sorting of bioactive molecules into exosomes, and exosome secretion. We also discuss preclinical studies in which stem cell-derived exosomes were successfully used to treat cardiovascular disease (CVD). Finally, we discuss the future possibility of exosome-based clinical treatment of CVD.
Publish Date 2016-09-19 15:28
Citation Suzuki E, Fujita D, Takahashi M, Oba S, Nishimatsu H. Stem cell-derived exosomes as a therapeutic tool for cardiovascular disease. World J Stem Cells 2016; 8(9): 297-305
URL http://www.wjgnet.com/1948-0210/full/v8/i9/297.htm
DOI http://dx.doi.org/10.4252/wjsc.v8.i9.297
Full Article (PDF) WJSC-8-297.pdf
Full Article (Word) WJSC-8-297.doc
Manuscript File 27369-Review.docx
Answering Reviewers 27369-Answering reviewers.pdf
Audio Core Tip 27369-Audio core tip.wav
Conflict-of-Interest Disclosure Form 27369-Conflict-of-interest statement.pdf
Copyright License Agreement 27369-Copyright assignment.pdf
Peer-review Report 27369-Peer-review(s).pdf
Scientific Misconduct Check 27369-Scientific misconduct check.pdf
Scientific Editor Work List 27369-Scientific editor work list.pdf